Akimoto M - Search Results

1

An auto-inhibited state of protein kinase G and implications for selective activation.

Sharma R, Kim JJ, Qin L, Henning P, Akimoto M, VanSchouwen B, Kaur G, Sankaran B, MacKenzie KR, Melacini G, Casteel DE, Herberg FW, Kim C. Sharma R, et al. Among authors: akimoto m. Elife. 2022 Aug 5;11:e79530. doi: 10.7554/eLife.79530. Elife. 2022. PMID: 35929723 Free PMC article.

2

cAMP-dependent allostery and dynamics in Epac: an NMR view.

Selvaratnam R, Akimoto M, VanSchouwen B, Melacini G. Selvaratnam R, et al. Among authors: akimoto m. Biochem Soc Trans. 2012 Feb;40(1):219-23. doi: 10.1042/BST20110628. Biochem Soc Trans. 2012. PMID: 22260694 Review.

3

Signaling through dynamic linkers as revealed by PKA.

Akimoto M, Selvaratnam R, McNicholl ET, Verma G, Taylor SS, Melacini G. Akimoto M, et al. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14231-6. doi: 10.1073/pnas.1312644110. Epub 2013 Aug 14. Proc Natl Acad Sci U S A. 2013. PMID: 23946424 Free PMC article.

4

A novel non-canonical forkhead-associated (FHA) domain-binding interface mediates the interaction between Rad53 and Dbf4 proteins.

Matthews LA, Selvaratnam R, Jones DR, Akimoto M, McConkey BJ, Melacini G, Duncker BP, Guarné A. Matthews LA, et al. Among authors: akimoto m. J Biol Chem. 2014 Jan 31;289(5):2589-99. doi: 10.1074/jbc.M113.517060. Epub 2013 Nov 27. J Biol Chem. 2014. PMID: 24285546 Free PMC article.

5

Allosteric linkers in cAMP signalling.

Akimoto M, Moleschi K, Boulton S, VanSchouwen B, Selvaratnam R, Taylor SS, Melacini G. Akimoto M, et al. Biochem Soc Trans. 2014 Feb;42(1):139-44. doi: 10.1042/BST20130257. Biochem Soc Trans. 2014. PMID: 24450641 Free PMC article. Review.

6

Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR.

Boulton S, Akimoto M, VanSchouwen B, Moleschi K, Selvaratnam R, Giri R, Melacini G. Boulton S, et al. Among authors: akimoto m. Biochem Soc Trans. 2014 Apr;42(2):302-7. doi: 10.1042/BST20130282. Biochem Soc Trans. 2014. PMID: 24646235 Review.

7

A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP.

Akimoto M, Zhang Z, Boulton S, Selvaratnam R, VanSchouwen B, Gloyd M, Accili EA, Lange OF, Melacini G. Akimoto M, et al. J Biol Chem. 2014 Aug 8;289(32):22205-20. doi: 10.1074/jbc.M114.572164. Epub 2014 May 30. J Biol Chem. 2014. PMID: 24878962 Free PMC article.

8

A tool set to map allosteric networks through the NMR chemical shift covariance analysis.

Boulton S, Akimoto M, Selvaratnam R, Bashiri A, Melacini G. Boulton S, et al. Among authors: akimoto m. Sci Rep. 2014 Dec 8;4:7306. doi: 10.1038/srep07306. Sci Rep. 2014. PMID: 25482377 Free PMC article.

9

Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels.

VanSchouwen B, Akimoto M, Sayadi M, Fogolari F, Melacini G. VanSchouwen B, et al. Among authors: akimoto m. J Biol Chem. 2015 Jul 17;290(29):17642-17654. doi: 10.1074/jbc.M115.651877. Epub 2015 May 4. J Biol Chem. 2015. PMID: 25944904 Free PMC article.

10

Measurement of State-Specific Association Constants in Allosteric Sensors through Molecular Stapling and NMR.

Moleschi KJ, Akimoto M, Melacini G. Moleschi KJ, et al. Among authors: akimoto m. J Am Chem Soc. 2015 Aug 26;137(33):10777-85. doi: 10.1021/jacs.5b06557. Epub 2015 Aug 17. J Am Chem Soc. 2015. PMID: 26247242

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