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Page 1
Chemical Space Mimicry for Drug Discovery.
Yuan W, Jiang D, Nambiar DK, Liew LP, Hay MP, Bloomstein J, Lu P, Turner B, Le QT, Tibshirani R, Khatri P, Moloney MG, Koong AC. Yuan W, et al. Among authors: nambiar dk. J Chem Inf Model. 2017 Apr 24;57(4):875-882. doi: 10.1021/acs.jcim.6b00754. Epub 2017 Apr 3. J Chem Inf Model. 2017. PMID: 28257191 Free PMC article.
Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.
Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, Knox SM, Le QT, Mochly-Rosen D. Saiki JP, et al. Among authors: nambiar dk. Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6279-6284. doi: 10.1073/pnas.1802184115. Epub 2018 May 24. Proc Natl Acad Sci U S A. 2018. PMID: 29794221 Free PMC article.
The role of Glial cell derived neurotrophic factor in head and neck cancer.
Cao H, He Q, Eyben RV, Bloomstein J, Nambiar DK, Viswanathan V, Aggarwal S, Kwok S, Liang R, Koong AJ, Lewis JS Jr, Kong C, Xiao N, Le QT. Cao H, et al. Among authors: nambiar dk. PLoS One. 2020 Feb 21;15(2):e0229311. doi: 10.1371/journal.pone.0229311. eCollection 2020. PLoS One. 2020. PMID: 32084217 Free PMC article.
Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer.
Tailor D, Going CC, Resendez A, Kumar V, Nambiar DK, Li Y, Dheeraj A, LaGory EL, Ghoochani A, Birk AM, Stoyanova T, Ye J, Giaccia AJ, Le QT, Singh RP, Sledge GW, Pitteri SJ, Malhotra SV. Tailor D, et al. Among authors: nambiar dk. Br J Cancer. 2021 Feb;124(3):604-615. doi: 10.1038/s41416-020-01137-4. Epub 2020 Nov 3. Br J Cancer. 2021. PMID: 33139797 Free PMC article.
Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer.
Tailor D, Resendez A, Garcia-Marques FJ, Pandrala M, Going CC, Bermudez A, Kumar V, Rafat M, Nambiar DK, Honkala A, Le QT, Sledge GW, Graves E, Pitteri SJ, Malhotra SV. Tailor D, et al. Among authors: nambiar dk. Cell Chem Biol. 2021 Aug 19;28(8):1206-1220.e6. doi: 10.1016/j.chembiol.2021.02.014. Epub 2021 Mar 12. Cell Chem Biol. 2021. PMID: 33713600 Free article.
Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype.
Viswanathan V, Cao H, Saiki J, Jiang D, Mattingly A, Nambiar D, Bloomstein J, Li Y, Jiang S, Chamoli M, Sirjani D, Kaplan M, Holsinger FC, Liang R, Von Eyben R, Jiang H, Guan L, Lagory E, Feng Z, Nolan G, Ye J, Denko N, Knox S, Rosen DM, Le QT. Viswanathan V, et al. PNAS Nexus. 2022 Jun 9;1(2):pgac056. doi: 10.1093/pnasnexus/pgac056. eCollection 2022 May. PNAS Nexus. 2022. PMID: 35707206 Free PMC article.
NFE2L2 Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells.
Guan L, Nambiar DK, Cao H, Viswanathan V, Kwok S, Hui AB, Hou Y, Hildebrand R, von Eyben R, Holmes BJ, Zhao J, Kong CS, Wamsley N, Zhang W, Major MB, Seol SW, Sunwoo JB, Hayes DN, Diehn M, Le QT. Guan L, et al. Among authors: nambiar dk. Cancer Res. 2023 Mar 15;83(6):861-874. doi: 10.1158/0008-5472.CAN-22-1903. Cancer Res. 2023. PMID: 36652552 Free PMC article.
29 results