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A novel N-heterocycles substituted oseltamivir derivatives as potent inhibitors of influenza virus neuraminidase: discovery, synthesis and biological evaluation.
Zhang J, Liu C, Jia R, Zhang X, Zhang J, Bertagnin C, Bonomini A, Guizzo L, Jiang Y, Jia H, Jia S, Ma X, Loregian A, Huang B, Zhan P, Liu X. Zhang J, et al. Among authors: guizzo l. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2277135. doi: 10.1080/14756366.2023.2277135. Epub 2023 Nov 13. J Enzyme Inhib Med Chem. 2023. PMID: 37955306 Free PMC article.
Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity.
Ju H, Hou L, Zhao F, Zhang Y, Jia R, Guizzo L, Bonomini A, Zhang J, Gao Z, Liang R, Bertagnin C, Kong X, Ma X, Kang D, Loregian A, Huang B, Liu X, Zhan P. Ju H, et al. Among authors: guizzo l. J Med Chem. 2022 Sep 8;65(17):11550-11573. doi: 10.1021/acs.jmedchem.1c01970. Epub 2022 Aug 8. J Med Chem. 2022. PMID: 35939763
Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.
Ju H, Murugan NA, Hou L, Li P, Guizzo L, Zhang Y, Bertagnin C, Kong X, Kang D, Jia R, Ma X, Du R, Poongavanam V, Loregian A, Huang B, Liu X, Zhan P. Ju H, et al. Among authors: guizzo l. J Med Chem. 2021 Dec 23;64(24):17992-18009. doi: 10.1021/acs.jmedchem.1c01366. Epub 2021 Nov 4. J Med Chem. 2021. PMID: 34735766