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Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity.
Ju H, Hou L, Zhao F, Zhang Y, Jia R, Guizzo L, Bonomini A, Zhang J, Gao Z, Liang R, Bertagnin C, Kong X, Ma X, Kang D, Loregian A, Huang B, Liu X, Zhan P. Ju H, et al. J Med Chem. 2022 Sep 8;65(17):11550-11573. doi: 10.1021/acs.jmedchem.1c01970. Epub 2022 Aug 8. J Med Chem. 2022. PMID: 35939763
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
Zhang J, Poongavanam V, Kang D, Bertagnin C, Lu H, Kong X, Ju H, Lu X, Gao P, Tian Y, Jia H, Desta S, Ding X, Sun L, Fang Z, Huang B, Liang X, Jia R, Ma X, Xu W, Murugan NA, Loregian A, Huang B, Zhan P, Liu X. Zhang J, et al. Among authors: ju h. J Med Chem. 2018 Jul 26;61(14):6379-6397. doi: 10.1021/acs.jmedchem.8b00929. Epub 2018 Jul 16. J Med Chem. 2018. PMID: 29965752
Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities.
Xiu S, Dick A, Ju H, Mirzaie S, Abdi F, Cocklin S, Zhan P, Liu X. Xiu S, et al. Among authors: ju h. J Med Chem. 2020 Nov 12;63(21):12256-12274. doi: 10.1021/acs.jmedchem.0c00502. Epub 2020 Jun 25. J Med Chem. 2020. PMID: 32539378 Free PMC article. Review.
Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.
Ju H, Murugan NA, Hou L, Li P, Guizzo L, Zhang Y, Bertagnin C, Kong X, Kang D, Jia R, Ma X, Du R, Poongavanam V, Loregian A, Huang B, Liu X, Zhan P. Ju H, et al. J Med Chem. 2021 Dec 23;64(24):17992-18009. doi: 10.1021/acs.jmedchem.1c01366. Epub 2021 Nov 4. J Med Chem. 2021. PMID: 34735766
2,411 results