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Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress.
Jobava R, Mao Y, Guan BJ, Hu D, Krokowski D, Chen CW, Shu XE, Chukwurah E, Wu J, Gao Z, Zagore LL, Merrick WC, Trifunovic A, Hsieh AC, Valadkhan S, Zhang Y, Qi X, Jankowsky E, Topisirovic I, Licatalosi DD, Qian SB, Hatzoglou M. Jobava R, et al. Among authors: chen cw. Mol Cell. 2021 Oct 21;81(20):4191-4208.e8. doi: 10.1016/j.molcel.2021.09.029. Mol Cell. 2021. PMID: 34686314 Free PMC article.
Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.
Krokowski D, Jobava R, Szkop KJ, Chen CW, Fu X, Venus S, Guan BJ, Wu J, Gao Z, Banaszuk W, Tchorzewski M, Mu T, Ropelewski P, Merrick WC, Mao Y, Sevval AI, Miranda H, Qian SB, Manifava M, Ktistakis NT, Vourekas A, Jankowsky E, Topisirovic I, Larsson O, Hatzoglou M. Krokowski D, et al. Among authors: chen cw. Cell Rep. 2022 Jul 19;40(3):111092. doi: 10.1016/j.celrep.2022.111092. Cell Rep. 2022. PMID: 35858571 Free PMC article.
Adaptation to chronic ER stress enforces pancreatic β-cell plasticity.
Chen CW, Guan BJ, Alzahrani MR, Gao Z, Gao L, Bracey S, Wu J, Mbow CA, Jobava R, Haataja L, Zalavadia AH, Schaffer AE, Lee H, LaFramboise T, Bederman I, Arvan P, Mathews CE, Gerling IC, Kaestner KH, Tirosh B, Engin F, Hatzoglou M. Chen CW, et al. Nat Commun. 2022 Aug 8;13(1):4621. doi: 10.1038/s41467-022-32425-7. Nat Commun. 2022. PMID: 35941159 Free PMC article.
Stress-induced β cell early senescence confers protection against type 1 diabetes.
Lee H, Sahin GS, Chen CW, Sonthalia S, Cañas SM, Oktay HZ, Duckworth AT, Brawerman G, Thompson PJ, Hatzoglou M, Eizirik DL, Engin F. Lee H, et al. Among authors: chen cw. Cell Metab. 2023 Dec 5;35(12):2200-2215.e9. doi: 10.1016/j.cmet.2023.10.014. Epub 2023 Nov 9. Cell Metab. 2023. PMID: 37949065 Free PMC article.
2,154 results