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Page 1
GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A2A Adenosine Receptor.
Shiriaeva A, Park D, Kim G, Lee Y, Hou X, Jarhad DB, Kim G, Yu J, Hyun YE, Kim W, Gao ZG, Jacobson KA, Han GW, Stevens RC, Jeong LS, Choi S, Cherezov V. Shiriaeva A, et al. Among authors: han gw. J Med Chem. 2022 Sep 8;65(17):11648-11657. doi: 10.1021/acs.jmedchem.2c00462. Epub 2022 Aug 17. J Med Chem. 2022. PMID: 35977382 Free PMC article.
Structure of an agonist-bound human A2A adenosine receptor.
Xu F, Wu H, Katritch V, Han GW, Jacobson KA, Gao ZG, Cherezov V, Stevens RC. Xu F, et al. Among authors: han gw. Science. 2011 Apr 15;332(6027):322-7. doi: 10.1126/science.1202793. Epub 2011 Mar 10. Science. 2011. PMID: 21393508 Free PMC article.
Structural characterization of three novel hydroxamate-based zinc chelating inhibitors of the Clostridium botulinum serotype A neurotoxin light chain metalloprotease reveals a compact binding site resulting from 60/70 loop flexibility.
Thompson AA, Jiao GS, Kim S, Thai A, Cregar-Hernandez L, Margosiak SA, Johnson AT, Han GW, O'Malley S, Stevens RC. Thompson AA, et al. Among authors: han gw. Biochemistry. 2011 May 17;50(19):4019-28. doi: 10.1021/bi2001483. Epub 2011 Apr 21. Biochemistry. 2011. PMID: 21434688 Free PMC article.
Structure of the human histamine H1 receptor complex with doxepin.
Shimamura T, Shiroishi M, Weyand S, Tsujimoto H, Winter G, Katritch V, Abagyan R, Cherezov V, Liu W, Han GW, Kobayashi T, Stevens RC, Iwata S. Shimamura T, et al. Among authors: han gw. Nature. 2011 Jun 22;475(7354):65-70. doi: 10.1038/nature10236. Nature. 2011. PMID: 21697825 Free PMC article.
Structure of the human κ-opioid receptor in complex with JDTic.
Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, Stevens RC. Wu H, et al. Among authors: han gw. Nature. 2012 Mar 21;485(7398):327-32. doi: 10.1038/nature10939. Nature. 2012. PMID: 22437504 Free PMC article.
Structural basis for allosteric regulation of GPCRs by sodium ions.
Liu W, Chun E, Thompson AA, Chubukov P, Xu F, Katritch V, Han GW, Roth CB, Heitman LH, IJzerman AP, Cherezov V, Stevens RC. Liu W, et al. Among authors: han gw. Science. 2012 Jul 13;337(6091):232-6. doi: 10.1126/science.1219218. Science. 2012. PMID: 22798613 Free PMC article.
Structure of the human smoothened receptor bound to an antitumour agent.
Wang C, Wu H, Katritch V, Han GW, Huang XP, Liu W, Siu FY, Roth BL, Cherezov V, Stevens RC. Wang C, et al. Among authors: han gw. Nature. 2013 May 16;497(7449):338-43. doi: 10.1038/nature12167. Epub 2013 May 1. Nature. 2013. PMID: 23636324 Free PMC article.
194 results