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Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors.
Iijima D, Sugama H, Awai N, Takahashi Y, Togashi Y, Takebe T, Xie J, Shen J, Ke Y, Akatsuka H, Kawaguchi T, Takedomi K, Kashima A, Nishio M, Inui Y, Yoneda H, Xia G, Iijima T. Iijima D, et al. Among authors: kawaguchi t. ACS Med Chem Lett. 2022 Aug 1;13(8):1351-1357. doi: 10.1021/acsmedchemlett.2c00280. eCollection 2022 Aug 11. ACS Med Chem Lett. 2022. PMID: 35978678 Free PMC article.
Discovery of Apararenone (MT-3995) as a Highly Selective, Potent, and Novel Nonsteroidal Mineralocorticoid Receptor Antagonist.
Iijima T, Katoh M, Takedomi K, Yamamoto Y, Akatsuka H, Shirata N, Nishi A, Takakuwa M, Watanabe Y, Munakata H, Koyama N, Ikeda T, Iguchi T, Kato H, Kikkawa K, Kawaguchi T. Iijima T, et al. Among authors: kawaguchi t. J Med Chem. 2022 Jun 23;65(12):8127-8143. doi: 10.1021/acs.jmedchem.2c00402. Epub 2022 Jun 2. J Med Chem. 2022. PMID: 35652647
Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor.
Iijima D, Sugama H, Takahashi Y, Hirai M, Togashi Y, Xie J, Shen J, Ke Y, Akatsuka H, Kawaguchi T, Takedomi K, Kashima A, Nishio M, Inui Y, Yoneda H, Xia G, Iijima T. Iijima D, et al. Among authors: kawaguchi t. J Med Chem. 2022 Aug 25;65(16):10882-10897. doi: 10.1021/acs.jmedchem.2c00834. Epub 2022 Aug 8. J Med Chem. 2022. PMID: 35939295
Robot-Assisted CT-guided Biopsy with an Artificial Intelligence-Based Needle-Path Generator: An Experimental Evaluation Using a Phantom Model.
Sato T, Kawai T, Shimohira M, Ohta K, Suzuki K, Nakayama K, Takikawa J, Kawaguchi T, Urano M, Ng KW, Leong SH, Hiwatashi A, Too CW. Sato T, et al. Among authors: kawaguchi t. J Vasc Interv Radiol. 2025 Jan 21:S1051-0443(25)00040-5. doi: 10.1016/j.jvir.2025.01.028. Online ahead of print. J Vasc Interv Radiol. 2025. PMID: 39848324
Efficacy of ramucirumab combined with erlotinib or osimertinib in untreated EGFR-mutated NSCLC patients with asymptomatic brain metastases: insights from molecular biomarkers in the RELAY-brain trial.
Kaneda H, Daga H, Okada A, Nakatani Y, Tani Y, Oka T, Sawa K, Sakai K, Nishio K, Kawaguchi T. Kaneda H, et al. Among authors: kawaguchi t. Invest New Drugs. 2025 Jan 23. doi: 10.1007/s10637-025-01505-y. Online ahead of print. Invest New Drugs. 2025. PMID: 39847172
Leucine-rich alpha-2 glycoprotein in combination with C-reactive protein for predicting endoscopic activity in Crohn's disease: a single-centre, cross-sectional study.
Takada Y, Kiyohara H, Mikami Y, Taguri M, Sakakibara R, Aoki Y, Nanki K, Kawaguchi T, Yoshimatsu Y, Sugimoto S, Sujino T, Takabayashi K, Hosoe N, Ogata H, Kato M, Iwao Y, Nakamoto N, Kanai T. Takada Y, et al. Among authors: kawaguchi t. Ann Med. 2025 Dec;57(1):2453083. doi: 10.1080/07853890.2025.2453083. Epub 2025 Jan 17. Ann Med. 2025. PMID: 39823192 Free PMC article.
IL1RL1 variant may affect the response to type 2 biologics in patients with severe asthma.
Nishi K, Matsumoto H, Sunadome H, Nagasaki T, Oguma T, Tashima N, Hayashi Y, Terada S, Morita K, Yoshimura C, Nishizaka Y, Sano A, Iwanaga T, Sano H, Haraguchi R, Tohda Y, Kawaguchi T, Matsuda F, Hirai T. Nishi K, et al. Among authors: kawaguchi t. ERJ Open Res. 2025 Jan 13;11(1):00448-2024. doi: 10.1183/23120541.00448-2024. eCollection 2025 Jan. ERJ Open Res. 2025. PMID: 39811553 Free PMC article.
2,678 results