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Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia.
Reglero C, Dieck CL, Zask A, Forouhar F, Laurent AP, Lin WW, Albero R, Miller HI, Ma C, Gastier-Foster JM, Loh ML, Tong L, Stockwell BR, Palomero T, Ferrando AA. Reglero C, et al. Among authors: forouhar f. Cancer Discov. 2022 Nov 2;12(11):2646-2665. doi: 10.1158/2159-8290.CD-22-0010. Cancer Discov. 2022. PMID: 35984649 Free PMC article.
Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors.
Iketani S, Forouhar F, Liu H, Hong SJ, Lin FY, Nair MS, Zask A, Huang Y, Xing L, Stockwell BR, Chavez A, Ho DD. Iketani S, et al. Among authors: forouhar f. Nat Commun. 2021 Apr 1;12(1):2016. doi: 10.1038/s41467-021-22362-2. Nat Commun. 2021. PMID: 33795671 Free PMC article.
Characterization of a patient-derived variant of GPX4 for precision therapy.
Liu H, Forouhar F, Seibt T, Saneto R, Wigby K, Friedman J, Xia X, Shchepinov MS, Ramesh SK, Conrad M, Stockwell BR. Liu H, et al. Among authors: forouhar f. Nat Chem Biol. 2022 Jan;18(1):91-100. doi: 10.1038/s41589-021-00915-2. Epub 2021 Dec 20. Nat Chem Biol. 2022. PMID: 34931062 Free PMC article.
Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19.
Liu H, Iketani S, Zask A, Khanizeman N, Bednarova E, Forouhar F, Fowler B, Hong SJ, Mohri H, Nair MS, Huang Y, Tay NES, Lee S, Karan C, Resnick SJ, Quinn C, Li W, Shion H, Xia X, Daniels JD, Bartolo-Cruz M, Farina M, Rajbhandari P, Jurtschenko C, Lauber MA, McDonald T, Stokes ME, Hurst BL, Rovis T, Chavez A, Ho DD, Stockwell BR. Liu H, et al. Among authors: forouhar f. Nat Commun. 2022 Apr 7;13(1):1891. doi: 10.1038/s41467-022-29413-2. Nat Commun. 2022. PMID: 35393402 Free PMC article.
Structures of bacterial biosynthetic arginine decarboxylases.
Forouhar F, Lew S, Seetharaman J, Xiao R, Acton TB, Montelione GT, Tong L. Forouhar F, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1562-6. doi: 10.1107/S1744309110040649. Epub 2010 Nov 16. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 21139196 Free PMC article.
158 results