Luo HB - Search Results

1

Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases.

Liu H, Wang Q, Huang Y, Deng J, Xie X, Zhu J, Yuan Y, He YM, Huang YY, Luo HB, He X. Liu H, et al. Among authors: luo hb. Eur J Med Chem. 2022 Nov 15;242:114631. doi: 10.1016/j.ejmech.2022.114631. Epub 2022 Aug 9. Eur J Med Chem. 2022. PMID: 35985255

2

Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor.

Chen SK, Zhao P, Shao YX, Li Z, Zhang C, Liu P, He X, Luo HB, Hu X. Chen SK, et al. Among authors: luo hb. Bioorg Med Chem Lett. 2012 May 1;22(9):3261-4. doi: 10.1016/j.bmcl.2012.03.026. Epub 2012 Mar 21. Bioorg Med Chem Lett. 2012. PMID: 22483586

3

Structure-based discovery of highly selective phosphodiesterase-9A inhibitors and implications for inhibitor design.

Meng F, Hou J, Shao YX, Wu PY, Huang M, Zhu X, Cai Y, Li Z, Xu J, Liu P, Luo HB, Wan Y, Ke H. Meng F, et al. Among authors: luo hb. J Med Chem. 2012 Oct 11;55(19):8549-58. doi: 10.1021/jm301189c. Epub 2012 Oct 1. J Med Chem. 2012. PMID: 22985069 Free PMC article.

4

Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease.

Lu C, Guo Y, Yan J, Luo Z, Luo HB, Yan M, Huang L, Li X. Lu C, et al. Among authors: luo z, luo hb. J Med Chem. 2013 Jul 25;56(14):5843-59. doi: 10.1021/jm400567s. Epub 2013 Jul 8. J Med Chem. 2013. PMID: 23799643

5

The molecular basis for the inhibition of phosphodiesterase-4D by three natural resveratrol analogs. Isolation, molecular docking, molecular dynamics simulations, binding free energy, and bioassay.

Zhao P, Chen SK, Cai YH, Lu X, Li Z, Cheng YK, Zhang C, Hu X, He X, Luo HB. Zhao P, et al. Among authors: luo hb. Biochim Biophys Acta. 2013 Oct;1834(10):2089-96. doi: 10.1016/j.bbapap.2013.07.004. Epub 2013 Jul 19. Biochim Biophys Acta. 2013. PMID: 23871879

6

Chemical constituents of Aloe barbadensis Miller and their inhibitory effects on phosphodiesterase-4D.

Zhong J, Huang Y, Ding W, Wu X, Wan J, Luo H. Zhong J, et al. Fitoterapia. 2013 Dec;91:159-165. doi: 10.1016/j.fitote.2013.08.027. Epub 2013 Sep 9. Fitoterapia. 2013. PMID: 24028970

7

Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.

Luo Z, Sheng J, Sun Y, Lu C, Yan J, Liu A, Luo HB, Huang L, Li X. Luo Z, et al. Among authors: luo hb. J Med Chem. 2013 Nov 27;56(22):9089-99. doi: 10.1021/jm401047q. Epub 2013 Nov 12. J Med Chem. 2013. PMID: 24160297

8

The molecular basis for the selectivity of tadalafil toward phosphodiesterase 5 and 6: a modeling study.

Huang YY, Li Z, Cai YH, Feng LJ, Wu Y, Li X, Luo HB. Huang YY, et al. Among authors: luo hb. J Chem Inf Model. 2013 Nov 25;53(11):3044-53. doi: 10.1021/ci400458z. Epub 2013 Nov 12. J Chem Inf Model. 2013. PMID: 24180640

9

Selaginpulvilins A-D, new phosphodiesterase-4 inhibitors with an unprecedented skeleton from Selaginella pulvinata.

Liu X, Luo HB, Huang YY, Bao JM, Tang GH, Chen YY, Wang J, Yin S. Liu X, et al. Among authors: luo hb. Org Lett. 2014 Jan 3;16(1):282-5. doi: 10.1021/ol403282f. Epub 2013 Dec 12. Org Lett. 2014. PMID: 24328835

10

Natural phosphodiesterase-4 (PDE4) inhibitors from Crotalaria ferruginea.

Liu YN, Huang YY, Bao JM, Cai YH, Guo YQ, Liu SN, Luo HB, Yin S. Liu YN, et al. Among authors: luo hb. Fitoterapia. 2014 Apr;94:177-82. doi: 10.1016/j.fitote.2014.02.010. Epub 2014 Mar 2. Fitoterapia. 2014. PMID: 24594242

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