Wang Q - Search Results

1

Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases.

Liu H, Wang Q, Huang Y, Deng J, Xie X, Zhu J, Yuan Y, He YM, Huang YY, Luo HB, He X. Liu H, et al. Among authors: wang q. Eur J Med Chem. 2022 Nov 15;242:114631. doi: 10.1016/j.ejmech.2022.114631. Epub 2022 Aug 9. Eur J Med Chem. 2022. PMID: 35985255

2

Discovery of Potent Phosphodiesterase-9 Inhibitors for the Treatment of Hepatic Fibrosis.

Wu Y, Wang Q, Jiang MY, Huang YY, Zhu Z, Han C, Tian YJ, Zhang B, Luo HB. Wu Y, et al. Among authors: wang q. J Med Chem. 2021 Jul 8;64(13):9537-9549. doi: 10.1021/acs.jmedchem.1c00862. Epub 2021 Jun 18. J Med Chem. 2021. PMID: 34142552

3

Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer.

Long H, Hu X, Wang B, Wang Q, Wang R, Liu S, Xiong F, Jiang Z, Zhang XQ, Ye WC, Wang H. Long H, et al. Among authors: wang h, wang b, wang r, wang q. J Med Chem. 2021 Aug 26;64(16):12089-12108. doi: 10.1021/acs.jmedchem.1c00735. Epub 2021 Aug 18. J Med Chem. 2021. PMID: 34404206

4

Design, synthesis and biological evaluation of chromone derivatives as novel protein kinase CK2 inhibitors.

Wang Q, Hu X, Shi W, Long H, Wang H. Wang Q, et al. Among authors: wang h. Bioorg Med Chem Lett. 2022 Aug 1;69:128799. doi: 10.1016/j.bmcl.2022.128799. Epub 2022 May 14. Bioorg Med Chem Lett. 2022. PMID: 35580724

5

Discovery of Eucalyptin C, derived from the fruits of Eucalyptus globulus Labill., as a novel selective PI3Kγ inhibitor for immunosuppressive treatment.

Hu XL, Shen W, Wang R, Long H, Wang Q, Feng JH, Pham TA, Xiong F, Ye WC, Wang H. Hu XL, et al. Among authors: wang h, wang r, wang q. Chin J Nat Med. 2021 Nov;19(11):844-855. doi: 10.1016/S1875-5364(21)60111-5. Chin J Nat Med. 2021. PMID: 34844723

6

Synthesis and Biological Evaluation of Celastrol Derivatives with Improved Cytotoxic Selectivity and Antitumor Activities.

Hu XL, He QW, Long H, Zhang LX, Wang R, Wang BL, Feng JH, Wang Q, Hou JQ, Zhang XQ, Ye WC, Wang H. Hu XL, et al. Among authors: wang h, wang r, wang bl, wang q. J Nat Prod. 2021 Jul 23;84(7):1954-1966. doi: 10.1021/acs.jnatprod.1c00262. Epub 2021 Jun 25. J Nat Prod. 2021. PMID: 34170694

7

Small Molecular Oligopeptides Adorned with Tryptophan Residues as Potent Antitumor Agents: Design, Synthesis, Bioactivity Assay, Computational Prediction, and Experimental Validation.

Xu H, Li T, Wang Q, Lv Y, Sun C, Yan R, Wu X, Jin Y, Wang Z. Xu H, et al. Among authors: wang q. J Chem Inf Model. 2025 Jan 16. doi: 10.1021/acs.jcim.4c01759. Online ahead of print. J Chem Inf Model. 2025. PMID: 39817413

8

BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation.

Wang Q, Li QR, Xu L, Yuan ZC, Liu X, Tang MJ, Luo M, Zhong XW, Ma Q, Guo XL. Wang Q, et al. World J Gastrointest Oncol. 2025 Jan 15;17(1):99376. doi: 10.4251/wjgo.v17.i1.99376. World J Gastrointest Oncol. 2025. PMID: 39817136 Free PMC article.

9

Explore Alteration of Lung and Gut Microbiota in a Murine Model of OVA-Induced Asthma Treated by CpG Oligodeoxynucleotides.

Wang Q, Ji J, Xiao S, Wang J, Yan X, Fang L. Wang Q, et al. J Inflamm Res. 2025 Jan 11;18:445-461. doi: 10.2147/JIR.S487916. eCollection 2025. J Inflamm Res. 2025. PMID: 39816955 Free PMC article.

10

Inhalable Carbonyl Sulfide Donor-Hybridized Selective Phosphodiesterase 10A Inhibitor for Treating Idiopathic Pulmonary Fibrosis by Inhibiting Tumor Growth Factor-β Signaling and Activating the cAMP/Protein Kinase A/cAMP Response Element-Binding Protein (CREB)/p53 Axis.

Wang Q, Liu X, Yuan H, Zhang F, Wu J, Yang D, Qian J, Huang YY, Chai G, Luo HB, Guo L. Wang Q, et al. ACS Pharmacol Transl Sci. 2024 Dec 28;8(1):256-269. doi: 10.1021/acsptsci.4c00671. eCollection 2025 Jan 10. ACS Pharmacol Transl Sci. 2024. PMID: 39816787

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