Brouwer KLR - Search Results

1

A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity.

Saran C, Fu D, Ho H, Klein A, Fallon JK, Honkakoski P, Brouwer KLR. Saran C, et al. Among authors: brouwer klr. Sci Rep. 2022 Aug 22;12(1):14333. doi: 10.1038/s41598-022-18174-z. Sci Rep. 2022. PMID: 35995956 Free PMC article.

2

Ritonavir, saquinavir, and efavirenz, but not nevirapine, inhibit bile acid transport in human and rat hepatocytes.

McRae MP, Lowe CM, Tian X, Bourdet DL, Ho RH, Leake BF, Kim RB, Brouwer KL, Kashuba AD. McRae MP, et al. J Pharmacol Exp Ther. 2006 Sep;318(3):1068-75. doi: 10.1124/jpet.106.102657. Epub 2006 May 23. J Pharmacol Exp Ther. 2006. PMID: 16720753

3

Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity.

Leslie EM, Watkins PB, Kim RB, Brouwer KL. Leslie EM, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):1170-8. doi: 10.1124/jpet.106.119073. Epub 2007 Mar 20. J Pharmacol Exp Ther. 2007. PMID: 17374746

4

Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity.

Marion TL, Leslie EM, Brouwer KL. Marion TL, et al. Mol Pharm. 2007 Nov-Dec;4(6):911-8. doi: 10.1021/mp0700357. Epub 2007 Oct 27. Mol Pharm. 2007. PMID: 17963355

5

Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport.

Wolf KK, Vora S, Webster LO, Generaux GT, Polli JW, Brouwer KL. Wolf KK, et al. Toxicol In Vitro. 2010 Feb;24(1):297-309. doi: 10.1016/j.tiv.2009.08.009. Epub 2009 Aug 23. Toxicol In Vitro. 2010. PMID: 19706322 Free PMC article.

6

Influence of seeding density and extracellular matrix on bile Acid transport and mrp4 expression in sandwich-cultured mouse hepatocytes.

Swift B, Brouwer KL. Swift B, et al. Mol Pharm. 2010 Apr 5;7(2):491-500. doi: 10.1021/mp900227a. Mol Pharm. 2010. PMID: 19968322 Free PMC article.

7

Plasma bile acid concentrations in patients with human immunodeficiency virus infection receiving protease inhibitor therapy: possible implications for hepatotoxicity.

McRae M, Rezk NL, Bridges AS, Corbett AH, Tien HC, Brouwer KL, Kashuba AD. McRae M, et al. Pharmacotherapy. 2010 Jan;30(1):17-24. doi: 10.1592/phco.30.1.17. Pharmacotherapy. 2010. PMID: 20030469 Free PMC article.

8

Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.

Swift B, Pfeifer ND, Brouwer KL. Swift B, et al. Drug Metab Rev. 2010 Aug;42(3):446-71. doi: 10.3109/03602530903491881. Drug Metab Rev. 2010. PMID: 20109035 Free PMC article. Review.

9

Sulindac and its metabolites inhibit multiple transport proteins in rat and human hepatocytes.

Lee JK, Paine MF, Brouwer KL. Lee JK, et al. J Pharmacol Exp Ther. 2010 Aug;334(2):410-8. doi: 10.1124/jpet.110.165852. Epub 2010 Apr 29. J Pharmacol Exp Ther. 2010. PMID: 20430841 Free PMC article.

10

Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes.

Marion TL, Perry CH, St Claire RL 3rd, Brouwer KL. Marion TL, et al. Toxicol Appl Pharmacol. 2012 May 15;261(1):1-9. doi: 10.1016/j.taap.2012.02.002. Epub 2012 Feb 11. Toxicol Appl Pharmacol. 2012. PMID: 22342602 Free PMC article.

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