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PTG-100, an Oral α4β7 Antagonist Peptide: Preclinical Development and Phase 1 and 2a Studies in Ulcerative Colitis.
Sandborn WJ, Mattheakis LC, Modi NB, Pugatch D, Bressler B, Lee S, Bhandari R, Kanwar B, Shames R, D'Haens G, Schreiber S, Danese S, Feagan B, Pai RK, Liu DY, Gupta S. Sandborn WJ, et al. Among authors: liu dy, d haens g. Gastroenterology. 2021 Dec;161(6):1853-1864.e10. doi: 10.1053/j.gastro.2021.08.045. Epub 2021 Aug 30. Gastroenterology. 2021. PMID: 34474038 Free article. Clinical Trial.
JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans.
Fourie AM, Cheng X, Chang L, Greving C, Li X, Knight B, Polidori D, Patrick A, Bains T, Steele R, Allen SJ, Patch RJ, Sun C, Somani S, Bhandari A, Liu D, Huie K, Li S, Rodriguez MA, Xue X, Kannan A, Kosoglou T, Sherlock JP, Towne J, Holland MC, Modi NB. Fourie AM, et al. Among authors: liu d. Sci Rep. 2024 Jul 30;14(1):17515. doi: 10.1038/s41598-024-67371-5. Sci Rep. 2024. PMID: 39080319 Free PMC article.
Targeted inhibition of Gus-expressing Enterococcus faecalis to promote intestinal stem cell and epithelial renovation contributes to the relief of irinotecan chemotoxicity by dehydrodiisoeugenol.
Gao R, Yue B, Lv C, Geng X, Yu Z, Wang H, Zhang B, Ai F, Wang Z, Liu D, Wang Z, Chen K, Dou W. Gao R, et al. Among authors: liu d. Acta Pharm Sin B. 2024 Dec;14(12):5286-5304. doi: 10.1016/j.apsb.2024.09.018. Epub 2024 Oct 18. Acta Pharm Sin B. 2024. PMID: 39807321 Free PMC article.
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