The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells.
Kurimchak AM, Herrera-Montávez C, Montserrat-Sangrà S, Araiza-Olivera D, Hu J, Neumann-Domer R, Kuruvilla M, Bellacosa A, Testa JR, Jin J, Duncan JS.
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Sci Signal. 2022 Aug 30;15(749):eabn2707. doi: 10.1126/scisignal.abn2707. Epub 2022 Aug 30.
Sci Signal. 2022.
PMID: 36041010
Free PMC article.