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Induction of the activating transcription factor-4 in the intratumoral CD8+ T cells sustains their viability and anti-tumor activities.
Lu Z, Bae EA, Verginadis II, Zhang H, Cho C, McBrearty N, George SS, Diehl JA, Koumenis C, Bradley LM, Fuchs SY. Lu Z, et al. Among authors: koumenis c. Cancer Immunol Immunother. 2023 Apr;72(4):815-826. doi: 10.1007/s00262-022-03286-2. Epub 2022 Sep 5. Cancer Immunol Immunother. 2023. PMID: 36063172 Free PMC article.
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.
Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M, Li Y, Gao Y, Liu H, Li C, Maity A, Thomas-Tikhonenko A, Perl AE, Koong A, Fuchs SY, Diehl JA, Mills IG, Ruggero D, Koumenis C. Hart LS, et al. Among authors: koumenis c. J Clin Invest. 2012 Dec;122(12):4621-34. doi: 10.1172/JCI62973. Epub 2012 Nov 12. J Clin Invest. 2012. PMID: 23143306 Free PMC article.
ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.
Dey S, Sayers CM, Verginadis II, Lehman SL, Cheng Y, Cerniglia GJ, Tuttle SW, Feldman MD, Zhang PJ, Fuchs SY, Diehl JA, Koumenis C. Dey S, et al. Among authors: koumenis c. J Clin Invest. 2015 Jul 1;125(7):2592-608. doi: 10.1172/JCI78031. Epub 2015 May 26. J Clin Invest. 2015. PMID: 26011642 Free PMC article.
Type I interferons mediate pancreatic toxicities of PERK inhibition.
Yu Q, Zhao B, Gui J, Katlinski KV, Brice A, Gao Y, Li C, Kushner JA, Koumenis C, Diehl JA, Fuchs SY. Yu Q, et al. Among authors: koumenis c. Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15420-5. doi: 10.1073/pnas.1516362112. Epub 2015 Dec 1. Proc Natl Acad Sci U S A. 2015. PMID: 26627716 Free PMC article.
168 results