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Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation.
Kuppusamy R, Hsu YT, Ke YY, Chang PW, Chang YC, Chang HF, Wang PC, Lin YH, Huang YC, Yeh TK, Chuang JY, Loh HH, Shih C, Chen CT, Yeh SH, Ueng SH. Kuppusamy R, et al. Among authors: chang hf, chang yc, chang pw. Eur J Med Chem. 2022 Dec 5;243:114728. doi: 10.1016/j.ejmech.2022.114728. Epub 2022 Aug 31. Eur J Med Chem. 2022. PMID: 36084534
Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone.
Lin SY, Tien YW, Ke YY, Chang YC, Chang HF, Ou LC, Law PY, Xi JH, Tao PL, Loh HH, Chao YS, Shih C, Chen CT, Yeh SH, Ueng SH. Lin SY, et al. Among authors: chang hf, chang yc. Bioorg Chem. 2022 Nov;128:105905. doi: 10.1016/j.bioorg.2022.105905. Epub 2022 Jun 2. Bioorg Chem. 2022. PMID: 35710525
Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia.
Huang YH, Lin SY, Ou LC, Huang WC, Chao PK, Chang YC, Chang HF, Lee PT, Yeh TK, Kuo YH, Tien YW, Xi JH, Tao PL, Chen PY, Chuang JY, Shih C, Chen CT, Tung CW, Loh HH, Ueng SH, Yeh SH. Huang YH, et al. Among authors: chang hf, chang yc. Cell Chem Biol. 2024 Nov 21;31(11):1885-1898.e10. doi: 10.1016/j.chembiol.2024.06.013. Epub 2024 Jul 17. Cell Chem Biol. 2024. PMID: 39025070
DBPR116, a Prodrug of BPRMU191, in Combination with Naltrexone as a Safer Opioid Analgesic Than Morphine via Peripheral Administration.
Lin SY, Chang YC, Tien YW, Kuo YH, Chang HF, Ou LC, Chen YP, Chang KH, Hsu YT, Huang YC, Yang CM, Law PY, Xi JH, Tao PL, Loh HH, Yeh TK, Zhuang H, Hsieh HP, Shih C, Chen CT, Yeh SH, Ueng SH. Lin SY, et al. Among authors: chang hf, chang kh, chang yc. J Med Chem. 2024 Nov 14;67(21):19777-19790. doi: 10.1021/acs.jmedchem.4c02107. Epub 2024 Oct 29. J Med Chem. 2024. PMID: 39473174
Correction: Hong et al. Anti-Proliferative and Pro-Apoptotic Effects of Licochalcone A through ROS-Mediated Cell Cycle Arrest and Apoptosis in Human Bladder Cancer Cells. Int. J. Mol. Sci. 2019, 20, 3820.
Hong SH, Cha HJ, Hwang-Bo H, Kim MY, Kim SY, Ji SY, Cheong J, Park C, Lee H, Kim GY, Moon SK, Yun SJ, Chang YC, Kim WJ, Choi YH. Hong SH, et al. Among authors: chang yc. Int J Mol Sci. 2024 Dec 19;25(24):13595. doi: 10.3390/ijms252413595. Int J Mol Sci. 2024. PMID: 39769511
4,343 results