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EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.
Mohammad F, Weissmann S, Leblanc B, Pandey DP, Højfeldt JW, Comet I, Zheng C, Johansen JV, Rapin N, Porse BT, Tvardovskiy A, Jensen ON, Olaciregui NG, Lavarino C, Suñol M, de Torres C, Mora J, Carcaboso AM, Helin K. Mohammad F, et al. Among authors: tvardovskiy a. Nat Med. 2017 Apr;23(4):483-492. doi: 10.1038/nm.4293. Epub 2017 Feb 27. Nat Med. 2017. PMID: 28263309
Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2.
Højfeldt JW, Laugesen A, Willumsen BM, Damhofer H, Hedehus L, Tvardovskiy A, Mohammad F, Jensen ON, Helin K. Højfeldt JW, et al. Among authors: tvardovskiy a. Nat Struct Mol Biol. 2018 Mar;25(3):225-232. doi: 10.1038/s41594-018-0036-6. Epub 2018 Feb 26. Nat Struct Mol Biol. 2018. PMID: 29483650 Free PMC article.
Phosphorylation of the FACT histone chaperone subunit SPT16 affects chromatin at RNA polymerase II transcriptional start sites in Arabidopsis.
Michl-Holzinger P, Obermeyer S, Markusch H, Pfab A, Ettner A, Bruckmann A, Babl S, Längst G, Schwartz U, Tvardovskiy A, Jensen ON, Osakabe A, Berger F, Grasser KD. Michl-Holzinger P, et al. Among authors: tvardovskiy a. Nucleic Acids Res. 2022 May 20;50(9):5014-5028. doi: 10.1093/nar/gkac293. Nucleic Acids Res. 2022. PMID: 35489065 Free PMC article.
Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability.
Gaggioli V, Lo CSY, Reverón-Gómez N, Jasencakova Z, Domenech H, Nguyen H, Sidoli S, Tvardovskiy A, Uruci S, Slotman JA, Chai Y, Gonçalves JGSCS, Manolika EM, Jensen ON, Wheeler D, Sridharan S, Chakrabarty S, Demmers J, Kanaar R, Groth A, Taneja N. Gaggioli V, et al. Among authors: tvardovskiy a. Nat Cell Biol. 2023 Jul;25(7):1017-1032. doi: 10.1038/s41556-023-01167-z. Epub 2023 Jul 6. Nat Cell Biol. 2023. PMID: 37414849 Free PMC article.
19 results