Liu WS - Search Results

1

Identification of the novel natural product inhibitors of SHP2 from the plant Toona sinensis: In vitro and in silico study.

Zhao JF, Wang RS, Lu SZ, Guo XJ, Chen Y, Li LH, Ding CH, Liu WS. Zhao JF, et al. Among authors: liu ws. Int J Biol Macromol. 2022 Nov 30;221:679-690. doi: 10.1016/j.ijbiomac.2022.09.042. Epub 2022 Sep 9. Int J Biol Macromol. 2022. PMID: 36096249

2

Screening potential FDA-approved inhibitors of the SARS-CoV-2 major protease 3CL^pro through high-throughput virtual screening and molecular dynamics simulation.

Liu WS, Li HG, Ding CH, Zhang HX, Wang RR, Li JQ. Liu WS, et al. Aging (Albany NY). 2021 Mar 7;13(5):6258-6272. doi: 10.18632/aging.202703. Epub 2021 Mar 7. Aging (Albany NY). 2021. PMID: 33678621 Free PMC article.

3

Identification of potential target endoribonuclease NSP15 inhibitors of SARS-COV-2 from natural products through high-throughput virtual screening and molecular dynamics simulation.

Hu LC, Ding CH, Li HY, Li ZZ, Chen Y, Li LP, Li WZ, Liu WS. Hu LC, et al. Among authors: liu ws. J Food Biochem. 2022 May;46(5):e14085. doi: 10.1111/jfbc.14085. Epub 2022 Feb 6. J Food Biochem. 2022. PMID: 35128681 Free PMC article.

4

Identification of natural product inhibitors of PTP1B based on high-throughput virtual screening strategy: In silico, in vitro and in vivo studies.

Zhao JF, Li LH, Guo XJ, Zhang HX, Tang LL, Ding CH, Liu WS. Zhao JF, et al. Among authors: liu ws. Int J Biol Macromol. 2023 Jul 15;243:125292. doi: 10.1016/j.ijbiomac.2023.125292. Epub 2023 Jun 9. Int J Biol Macromol. 2023. PMID: 37302637

5

Design, synthesis, activity and molecular dynamics studies of 1,3,4-thiadiazole derivatives as selective allosteric inhibitors of SHP2 for the treatment of cancer.

Liu WS, Zhao JF, Guo XJ, Lu SZ, Li W, Li WZ. Liu WS, et al. Eur J Med Chem. 2023 Oct 5;258:115585. doi: 10.1016/j.ejmech.2023.115585. Epub 2023 Jun 24. Eur J Med Chem. 2023. PMID: 37390510

6

Discovery of ellagic acid as a competitive inhibitor of Src homology phosphotyrosyl phosphatase 2 (SHP2) for cancer treatment: In vitro and in silico study.

Ma CH, Zhao JF, Zhang XG, Ding CH, Hao HH, Ji YH, Li LP, Guo ZT, Liu WS. Ma CH, et al. Among authors: liu ws. Int J Biol Macromol. 2024 Jan;254(Pt 2):127845. doi: 10.1016/j.ijbiomac.2023.127845. Epub 2023 Nov 5. Int J Biol Macromol. 2024. PMID: 37935292

7

Discovery of 1H-pyrazolo[3,4-b]pyrazine derivatives as selective allosteric inhibitor of protein tyrosine phosphatase SHP2 for the treatment of KRAS^G12C-mutant non-small cell lung cancer.

Xu WQ, Qi SZ, Zhao JF, Li LP, Ding CH, Liu WS. Xu WQ, et al. Among authors: liu ws. J Biomol Struct Dyn. 2024 Jan 23:1-9. doi: 10.1080/07391102.2024.2308771. Online ahead of print. J Biomol Struct Dyn. 2024. PMID: 38258435

8

Design, synthesis and biological evaluation of pyridine derivatives as selective SHP2 inhibitors.

Liu WS, Yang B, Wang RR, Li WY, Ma YC, Zhou L, Du S, Ma Y, Wang RL. Liu WS, et al. Bioorg Chem. 2020 Jul;100:103875. doi: 10.1016/j.bioorg.2020.103875. Epub 2020 Apr 25. Bioorg Chem. 2020. PMID: 32380342

9

Structure based design of selective SHP2 inhibitors by De novo design, synthesis and biological evaluation.

Liu WS, Jin WY, Zhou L, Lu XH, Li WY, Ma Y, Wang RL. Liu WS, et al. J Comput Aided Mol Des. 2019 Aug;33(8):759-774. doi: 10.1007/s10822-019-00213-z. Epub 2019 Jul 12. J Comput Aided Mol Des. 2019. PMID: 31300938

10

Exploring the effect of D61G mutation on SHP2 cause gain of function activity by a molecular dynamics study.

Li HL, Ma Y, Zheng CJ, Jin WY, Liu WS, Wang RL. Li HL, et al. Among authors: liu ws. J Biomol Struct Dyn. 2018 Nov;36(14):3856-3868. doi: 10.1080/07391102.2017.1402709. Epub 2017 Nov 24. J Biomol Struct Dyn. 2018. PMID: 29125030

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