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CCRK is a novel signalling hub exploitable in cancer immunotherapy.
Mok MT, Zhou J, Tang W, Zeng X, Oliver AW, Ward SE, Cheng AS. Mok MT, et al. Among authors: tang w. Pharmacol Ther. 2018 Jun;186:138-151. doi: 10.1016/j.pharmthera.2018.01.008. Epub 2018 Mar 1. Pharmacol Ther. 2018. PMID: 29360538 Review.
Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.
Lee YY, Mok MT, Kang W, Yang W, Tang W, Wu F, Xu L, Yan M, Yu Z, Lee SD, Tong JHM, Cheung YS, Lai PBS, Yu DY, Wang Q, Wong GLH, Chan AM, Yip KY, To KF, Cheng ASL. Lee YY, et al. Among authors: tang w. Nucleic Acids Res. 2018 Sep 28;46(17):8832-8847. doi: 10.1093/nar/gky589. Nucleic Acids Res. 2018. PMID: 29992318 Free PMC article.
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma.
Sun H, Yang W, Tian Y, Zeng X, Zhou J, Mok MTS, Tang W, Feng Y, Xu L, Chan AWH, Tong JH, Cheung YS, Lai PBS, Wang HKS, Tsang SW, Chow KL, Hu M, Liu R, Huang L, Yang B, Yang P, To KF, Sung JJY, Wong GLH, Wong VWS, Cheng ASL. Sun H, et al. Among authors: tang w. Nat Commun. 2018 Dec 6;9(1):5214. doi: 10.1038/s41467-018-07402-8. Nat Commun. 2018. PMID: 30523261 Free PMC article.
Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis.
Zeng X, Zhou J, Xiong Z, Sun H, Yang W, Mok MTS, Wang J, Li J, Liu M, Tang W, Feng Y, Wang HK, Tsang SW, Chow KL, Yeung PC, Wong J, Lai PB, Chan AW, To KF, Chan SL, Xia Q, Xue J, Chen X, Yu J, Peng S, Sung JJ, Kuang M, Cheng AS. Zeng X, et al. Among authors: tang w. Cell Mol Immunol. 2021 Apr;18(4):1005-1015. doi: 10.1038/s41423-020-00534-2. Epub 2020 Sep 2. Cell Mol Immunol. 2021. PMID: 32879468 Free PMC article.
A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma.
Yang W, Feng Y, Zhou J, Cheung OK, Cao J, Wang J, Tang W, Tu Y, Xu L, Wu F, Tan Z, Sun H, Tian Y, Wong J, Lai PB, Chan SL, Chan AW, Tan PB, Chen Z, Sung JJ, Yip KY, To KF, Cheng AS. Yang W, et al. Among authors: tang w. Sci Transl Med. 2021 Apr 7;13(588):eaaz6804. doi: 10.1126/scitranslmed.aaz6804. Sci Transl Med. 2021. PMID: 33827976
Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver.
Tang W, Zhou J, Yang W, Feng Y, Wu H, Mok MTS, Zhang L, Liang Z, Liu X, Xiong Z, Zeng X, Wang J, Lu J, Li J, Sun H, Tian X, Yeung PC, Hou Y, Lee HM, Lam CCH, Leung HHW, Chan AWH, To KF, Wong J, Lai PBS, Ng KKC, Wong SKH, Wong VWS, Kong APS, Sung JJY, Cheng ASL. Tang W, et al. Cell Mol Immunol. 2022 Jul;19(7):834-847. doi: 10.1038/s41423-022-00872-3. Epub 2022 May 20. Cell Mol Immunol. 2022. PMID: 35595819 Free PMC article.
Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma.
Xiong Z, Chan SL, Zhou J, Vong JSL, Kwong TT, Zeng X, Wu H, Cao J, Tu Y, Feng Y, Yang W, Wong PP, Si-Tou WW, Liu X, Wang J, Tang W, Liang Z, Lu J, Li KM, Low JT, Chan MW, Leung HHW, Chan AWH, To KF, Yip KY, Lo YMD, Sung JJ, Cheng AS. Xiong Z, et al. Among authors: tang w. Gut. 2023 Sep;72(9):1758-1773. doi: 10.1136/gutjnl-2022-328364. Epub 2023 Apr 5. Gut. 2023. PMID: 37019619 Free PMC article.
PPP1R15A-expressing monocytic MDSCs promote immunosuppressive liver microenvironment in fibrosis-associated hepatocellular carcinoma.
Liu X, Liu M, Wu H, Tang W, Yang W, Chan TTH, Zhang L, Chen S, Xiong Z, Liang J, Wai-Yiu Si-Tou W, Shu T, Li J, Cao J, Zhong C, Sun H, Kwong TT, Leung HHW, Wong J, Bo-San Lai P, To KF, Xiang T, Jao-Yiu Sung J, Chan SL, Zhou J, Sze-Lok Cheng A. Liu X, et al. Among authors: tang w. JHEP Rep. 2024 Apr 4;6(7):101087. doi: 10.1016/j.jhepr.2024.101087. eCollection 2024 Jul. JHEP Rep. 2024. PMID: 38882672 Free PMC article.
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