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Linker-Dependent Folding Rationalizes PROTAC Cell Permeability.
Poongavanam V, Atilaw Y, Siegel S, Giese A, Lehmann L, Meibom D, Erdelyi M, Kihlberg J. Poongavanam V, et al. J Med Chem. 2022 Oct 13;65(19):13029-13040. doi: 10.1021/acs.jmedchem.2c00877. Epub 2022 Sep 28. J Med Chem. 2022. PMID: 36170570 Free PMC article.
Drug Syntheses Beyond the Rule of 5.
Tyagi M, Begnini F, Poongavanam V, Doak BC, Kihlberg J. Tyagi M, et al. Among authors: poongavanam v. Chemistry. 2020 Jan 2;26(1):49-88. doi: 10.1002/chem.201902716. Epub 2019 Oct 11. Chemistry. 2020. PMID: 31483909 Review.
Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1.
Yang J, Talibov VO, Peintner S, Rhee C, Poongavanam V, Geitmann M, Sebastiano MR, Simon B, Hennig J, Dobritzsch D, Danielson UH, Kihlberg J. Yang J, et al. Among authors: poongavanam v. ACS Omega. 2020 Feb 17;5(8):3979-3995. doi: 10.1021/acsomega.9b03493. eCollection 2020 Mar 3. ACS Omega. 2020. PMID: 32149225 Free PMC article.
59 results