Schofield CJ - Search Results

1

Can Second Coordination Sphere and Long-Range Interactions Modulate Hydrogen Atom Transfer in a Non-Heme Fe(II)-Dependent Histone Demethylase?

Chaturvedi SS, Jaber Sathik Rifayee SB, Waheed SO, Wildey J, Warner C, Schofield CJ, Karabencheva-Christova TG, Christov CZ. Chaturvedi SS, et al. Among authors: schofield cj. JACS Au. 2022 Aug 18;2(9):2169-2186. doi: 10.1021/jacsau.2c00345. eCollection 2022 Sep 26. JACS Au. 2022. PMID: 36186565 Free PMC article.

2

Conformational flexibility influences structure-function relationships in nucleic acid N-methyl demethylases.

Waheed SO , Ramanan R , Chaturvedi SS , Ainsley J , Evison M , Ames JM , Schofield CJ , Christov CZ , Karabencheva-Christova TG . Waheed SO , et al. Among authors: schofield cj. Org Biomol Chem. 2019 Feb 20;17(8):2223-2231. doi: 10.1039/c9ob00162j. Org Biomol Chem. 2019. PMID: 30720838

3

Conformational Dynamics Underlies Different Functions of Human KDM7 Histone Demethylases.

Chaturvedi SS, Ramanan R, Waheed SO, Ainsley J, Evison M, Ames JM, Schofield CJ, Karabencheva-Christova TG, Christov CZ. Chaturvedi SS, et al. Among authors: schofield cj. Chemistry. 2019 Apr 11;25(21):5422-5426. doi: 10.1002/chem.201900492. Epub 2019 Mar 26. Chemistry. 2019. PMID: 30817054

4

Catalysis by the Non-Heme Iron(II) Histone Demethylase PHF8 Involves Iron Center Rearrangement and Conformational Modulation of Substrate Orientation.

Chaturvedi SS, Ramanan R, Lehnert N, Schofield CJ, Karabencheva-Christova TG, Christov CZ. Chaturvedi SS, et al. Among authors: schofield cj. ACS Catal. 2020 Jan 17;10(2):1195-1209. doi: 10.1021/acscatal.9b04907. Epub 2019 Dec 11. ACS Catal. 2020. PMID: 31976154 Free PMC article.

5

Role of Structural Dynamics in Selectivity and Mechanism of Non-heme Fe(II) and 2-Oxoglutarate-Dependent Oxygenases Involved in DNA Repair.

Waheed SO, Ramanan R, Chaturvedi SS, Lehnert N, Schofield CJ, Christov CZ, Karabencheva-Christova TG. Waheed SO, et al. Among authors: schofield cj. ACS Cent Sci. 2020 May 27;6(5):795-814. doi: 10.1021/acscentsci.0c00312. Epub 2020 May 8. ACS Cent Sci. 2020. PMID: 32490196 Free PMC article.

6

What Is the Catalytic Mechanism of Enzymatic Histone N-Methyl Arginine Demethylation and Can It Be Influenced by an External Electric Field?

Ramanan R, Waheed SO, Schofield CJ, Christov CZ. Ramanan R, et al. Among authors: schofield cj. Chemistry. 2021 Aug 16;27(46):11827-11836. doi: 10.1002/chem.202101174. Epub 2021 Jun 4. Chemistry. 2021. PMID: 33989435 Free PMC article.

7

Catalysis by the JmjC histone demethylase KDM4A integrates substrate dynamics, correlated motions and molecular orbital control.

Ramanan R, Chaturvedi SS, Lehnert N, Schofield CJ, Karabencheva-Christova TG, Christov CZ. Ramanan R, et al. Among authors: schofield cj. Chem Sci. 2020 Sep 4;11(36):9950-9961. doi: 10.1039/d0sc03713c. Chem Sci. 2020. PMID: 34094257 Free PMC article.

8

What Is the Catalytic Mechanism of Enzymatic Histone N-Methyl Arginine Demethylation and Can It Be Influenced by an External Electric Field?

Ramanan R, Waheed SO, Schofield CJ, Christov CZ. Ramanan R, et al. Among authors: schofield cj. Chemistry. 2021 Aug 16;27(46):11750. doi: 10.1002/chem.202102158. Epub 2021 Jun 30. Chemistry. 2021. PMID: 34191375

9

Dynamical Nonequilibrium Molecular Dynamics Simulations Identify Allosteric Sites and Positions Associated with Drug Resistance in the SARS-CoV-2 Main Protease.

Chan HTH, Oliveira ASF, Schofield CJ, Mulholland AJ, Duarte F. Chan HTH, et al. Among authors: schofield cj. JACS Au. 2023 Jun 7;3(6):1767-1774. doi: 10.1021/jacsau.3c00185. eCollection 2023 Jun 26. JACS Au. 2023. PMID: 37384148 Free PMC article.

10

Unusual catalytic strategy by non-heme Fe(ii)/2-oxoglutarate-dependent aspartyl hydroxylase AspH.

Krishnan A, Waheed SO, Varghese A, Cherilakkudy FH, Schofield CJ, Karabencheva-Christova TG. Krishnan A, et al. Among authors: schofield cj. Chem Sci. 2024 Feb 5;15(10):3466-3484. doi: 10.1039/d3sc05974j. eCollection 2024 Mar 6. Chem Sci. 2024. PMID: 38455014 Free PMC article.

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