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BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma.
Tamai K, Nakamura-Shima M, Shibuya-Takahashi R, Kanno SI, Yasui A, Mochizuki M, Iwai W, Wakui Y, Abue M, Yamamoto K, Miura K, Mizuma M, Unno M, Kawamura S, Sato I, Yasuda J, Yamaguchi K, Sugamura K, Satoh K. Tamai K, et al. Among authors: wakui y. Sci Rep. 2020 Dec 9;10(1):21592. doi: 10.1038/s41598-020-78539-0. Sci Rep. 2020. PMID: 33299012 Free PMC article.
Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein.
Saijoh S, Nakamura-Shima M, Shibuya-Takahashi R, Ito R, Sugawara A, Yamazaki T, Imai T, Asada Y, Matsuura K, Iwai W, Wakui Y, Abue M, Kawamura S, Katayose Y, Fujimori H, Mochizuki M, Yasuda J, Yamaguchi K, Sugamura K, Satoh K, Katori Y, Tamai K. Saijoh S, et al. Among authors: wakui y. Biochem Biophys Res Commun. 2021 Jan 22;537:132-139. doi: 10.1016/j.bbrc.2020.11.022. Epub 2021 Jan 4. Biochem Biophys Res Commun. 2021. PMID: 33412384
BEX2 is required for maintaining dormant cancer stem cell in hepatocellular carcinoma.
Fukushi D, Shibuya-Takahashi R, Mochizuki M, Fujimori H, Kogure T, Sugai T, Iwai W, Wakui Y, Abue M, Murakami K, Nakamura Y, Yasuda J, Yamaguchi K, Sugamura K, Shibata C, Katayose Y, Satoh K, Tamai K. Fukushi D, et al. Among authors: wakui y. Cancer Sci. 2021 Nov;112(11):4580-4592. doi: 10.1111/cas.15115. Epub 2021 Sep 4. Cancer Sci. 2021. PMID: 34424582 Free PMC article.
BEX2 is poor prognostic factor and required for cancer stemness in gastric cancer.
Yasumoto A, Fujimori H, Mochizuki M, Shibuya-Takahashi R, Nakamura-Shima M, Shindo N, Yamaguchi K, Fukushi D, Wakui Y, Sugai T, Iwai W, Abue M, Sato I, Satoh K, Katayose Y, Yasuda J, Shibata C, Tamai K. Yasumoto A, et al. Among authors: wakui y. Biochem Biophys Res Commun. 2023 May 7;655:59-67. doi: 10.1016/j.bbrc.2023.03.025. Epub 2023 Mar 11. Biochem Biophys Res Commun. 2023. PMID: 36933308
Delta-6 desaturase FADS2 is a tumor-promoting factor in cholangiocarcinoma.
Hasegawa K, Fujimori H, Nakatani K, Takahashi M, Izumi Y, Bamba T, Nakamura-Shima M, Shibuya-Takahashi R, Mochizuki M, Wakui Y, Abue M, Iwai W, Fukushi D, Satoh K, Yamaguchi K, Shindo N, Yasuda J, Asano N, Imai T, Asada Y, Katori Y, Tamai K. Hasegawa K, et al. Among authors: wakui y. Cancer Sci. 2024 Oct;115(10):3346-3357. doi: 10.1111/cas.16306. Epub 2024 Aug 7. Cancer Sci. 2024. PMID: 39113435 Free PMC article.
69 results