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Page 1
Clinical implications of T cell exhaustion for cancer immunotherapy.
Chow A, Perica K, Klebanoff CA, Wolchok JD. Chow A, et al. Among authors: wolchok jd. Nat Rev Clin Oncol. 2022 Dec;19(12):775-790. doi: 10.1038/s41571-022-00689-z. Epub 2022 Oct 10. Nat Rev Clin Oncol. 2022. PMID: 36216928 Free PMC article. Review.
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells.
De Henau O, Rausch M, Winkler D, Campesato LF, Liu C, Cymerman DH, Budhu S, Ghosh A, Pink M, Tchaicha J, Douglas M, Tibbitts T, Sharma S, Proctor J, Kosmider N, White K, Stern H, Soglia J, Adams J, Palombella VJ, McGovern K, Kutok JL, Wolchok JD, Merghoub T. De Henau O, et al. Among authors: wolchok jd. Nature. 2016 Nov 17;539(7629):443-447. doi: 10.1038/nature20554. Epub 2016 Nov 9. Nature. 2016. PMID: 27828943 Free PMC article.
Chromatin states define tumour-specific T cell dysfunction and reprogramming.
Philip M, Fairchild L, Sun L, Horste EL, Camara S, Shakiba M, Scott AC, Viale A, Lauer P, Merghoub T, Hellmann MD, Wolchok JD, Leslie CS, Schietinger A. Philip M, et al. Among authors: wolchok jd. Nature. 2017 May 25;545(7655):452-456. doi: 10.1038/nature22367. Epub 2017 May 17. Nature. 2017. PMID: 28514453 Free PMC article.
Shared cancer neoantigens: Making private matters public.
Klebanoff CA, Wolchok JD. Klebanoff CA, et al. Among authors: wolchok jd. J Exp Med. 2018 Jan 2;215(1):5-7. doi: 10.1084/jem.20172188. Epub 2017 Dec 21. J Exp Med. 2018. PMID: 29269561 Free PMC article.
Tumor mutational load predicts survival after immunotherapy across multiple cancer types.
Samstein RM, Lee CH, Shoushtari AN, Hellmann MD, Shen R, Janjigian YY, Barron DA, Zehir A, Jordan EJ, Omuro A, Kaley TJ, Kendall SM, Motzer RJ, Hakimi AA, Voss MH, Russo P, Rosenberg J, Iyer G, Bochner BH, Bajorin DF, Al-Ahmadie HA, Chaft JE, Rudin CM, Riely GJ, Baxi S, Ho AL, Wong RJ, Pfister DG, Wolchok JD, Barker CA, Gutin PH, Brennan CW, Tabar V, Mellinghoff IK, DeAngelis LM, Ariyan CE, Lee N, Tap WD, Gounder MM, D'Angelo SP, Saltz L, Stadler ZK, Scher HI, Baselga J, Razavi P, Klebanoff CA, Yaeger R, Segal NH, Ku GY, DeMatteo RP, Ladanyi M, Rizvi NA, Berger MF, Riaz N, Solit DB, Chan TA, Morris LGT. Samstein RM, et al. Among authors: wolchok jd. Nat Genet. 2019 Feb;51(2):202-206. doi: 10.1038/s41588-018-0312-8. Epub 2019 Jan 14. Nat Genet. 2019. PMID: 30643254 Free PMC article.
Rational design of anti-GITR-based combination immunotherapy.
Zappasodi R, Sirard C, Li Y, Budhu S, Abu-Akeel M, Liu C, Yang X, Zhong H, Newman W, Qi J, Wong P, Schaer D, Koon H, Velcheti V, Hellmann MD, Postow MA, Callahan MK, Wolchok JD, Merghoub T. Zappasodi R, et al. Among authors: wolchok jd. Nat Med. 2019 May;25(5):759-766. doi: 10.1038/s41591-019-0420-8. Epub 2019 Apr 29. Nat Med. 2019. PMID: 31036879 Free PMC article. Clinical Trial.
In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors.
Khalil DN, Suek N, Campesato LF, Budhu S, Redmond D, Samstein RM, Krishna C, Panageas KS, Capanu M, Houghton S, Hirschhorn D, Zappasodi R, Giese R, Gasmi B, Schneider M, Gupta A, Harding JJ, Moral JA, Balachandran VP, Wolchok JD, Merghoub T. Khalil DN, et al. Among authors: wolchok jd. J Clin Invest. 2019 Jul 22;129(8):3435-3447. doi: 10.1172/JCI128562. eCollection 2019 Jul 22. J Clin Invest. 2019. PMID: 31329159 Free PMC article.
480 results