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Structural principles of B cell antigen receptor assembly.
Dong Y, Pi X, Bartels-Burgahn F, Saltukoglu D, Liang Z, Yang J, Alt FW, Reth M, Wu H. Dong Y, et al. Among authors: wu h. Nature. 2022 Dec;612(7938):156-161. doi: 10.1038/s41586-022-05412-7. Epub 2022 Oct 13. Nature. 2022. PMID: 36228656 Free PMC article.
AID Recognizes Structured DNA for Class Switch Recombination.
Qiao Q, Wang L, Meng FL, Hwang JK, Alt FW, Wu H. Qiao Q, et al. Among authors: wu h. Mol Cell. 2017 Aug 3;67(3):361-373.e4. doi: 10.1016/j.molcel.2017.06.034. Epub 2017 Jul 27. Mol Cell. 2017. PMID: 28757211 Free PMC article.
Cryo-EM structure of the gasdermin A3 membrane pore.
Ruan J, Xia S, Liu X, Lieberman J, Wu H. Ruan J, et al. Among authors: wu h. Nature. 2018 May;557(7703):62-67. doi: 10.1038/s41586-018-0058-6. Epub 2018 Apr 25. Nature. 2018. PMID: 29695864 Free PMC article.
DNA melting initiates the RAG catalytic pathway.
Ru H, Mi W, Zhang P, Alt FW, Schatz DG, Liao M, Wu H. Ru H, et al. Among authors: wu h. Nat Struct Mol Biol. 2018 Aug;25(8):732-742. doi: 10.1038/s41594-018-0098-5. Epub 2018 Jul 30. Nat Struct Mol Biol. 2018. PMID: 30061602 Free PMC article.
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.
Sharif H, Wang L, Wang WL, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Núñez G, Mao Y, Wu H. Sharif H, et al. Among authors: wu h, wu z. Nature. 2019 Jun;570(7761):338-343. doi: 10.1038/s41586-019-1295-z. Epub 2019 Jun 12. Nature. 2019. PMID: 31189953 Free PMC article.
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Robert Hollingsworth L, David L, Li Y, Griswold AR, Ruan J, Sharif H, Fontana P, Orth-He EL, Fu TM, Bachovchin DA, Wu H. Robert Hollingsworth L, et al. Among authors: wu h. Nat Commun. 2021 Jan 8;12(1):189. doi: 10.1038/s41467-020-20320-y. Nat Commun. 2021. PMID: 33420033 Free PMC article.
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Hollingsworth LR, Sharif H, Griswold AR, Fontana P, Mintseris J, Dagbay KB, Paulo JA, Gygi SP, Bachovchin DA, Wu H. Hollingsworth LR, et al. Among authors: wu h. Nature. 2021 Apr;592(7856):778-783. doi: 10.1038/s41586-021-03350-4. Epub 2021 Mar 17. Nature. 2021. PMID: 33731932 Free PMC article.
Gasdermin D pore structure reveals preferential release of mature interleukin-1.
Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, Wang L, Fu TM, Jacobson MP, Greka A, Lieberman J, Ruan J, Wu H. Xia S, et al. Among authors: wu h. Nature. 2021 May;593(7860):607-611. doi: 10.1038/s41586-021-03478-3. Epub 2021 Apr 21. Nature. 2021. PMID: 33883744 Free PMC article.
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