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Reset of Inflammatory Priming of Joint Tissue and Reduction of the Severity of Arthritis Flares by Bromodomain Inhibition.
Friščić J, Reinwald C, Böttcher M, Houtman M, Euler M, Chen X, Walker KI, Kirchner P, Zhu H, Wirth B, Weidner D, Krüger R, Trajkovic V, Ekici AB, Klein K, Mougiakakos D, Ospelt C, Schett G, Hoffmann MH. Friščić J, et al. Among authors: walker ki. Arthritis Rheumatol. 2023 Apr;75(4):517-532. doi: 10.1002/art.42378. Epub 2023 Feb 2. Arthritis Rheumatol. 2023. PMID: 36245290 Free article.
The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.
Friščić J, Böttcher M, Reinwald C, Bruns H, Wirth B, Popp SJ, Walker KI, Ackermann JA, Chen X, Turner J, Zhu H, Seyler L, Euler M, Kirchner P, Krüger R, Ekici AB, Major T, Aust O, Weidner D, Fischer A, Andes FT, Stanojevic Z, Trajkovic V, Herrmann M, Korb-Pap A, Wank I, Hess A, Winter J, Wixler V, Distler J, Steiner G, Kiener HP, Frey B, Kling L, Raza K, Frey S, Kleyer A, Bäuerle T, Hughes TR, Grüneboom A, Steffen U, Krönke G, Croft AP, Filer A, Köhl J, Klein K, Buckley CD, Schett G, Mougiakakos D, Hoffmann MH. Friščić J, et al. Among authors: walker ki. Immunity. 2021 May 11;54(5):1002-1021.e10. doi: 10.1016/j.immuni.2021.03.003. Epub 2021 Mar 23. Immunity. 2021. PMID: 33761330 Free article.