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Transcriptional and functional analyses of neoantigen-specific CD4 T cells during a profound response to anti-PD-L1 in metastatic Merkel cell carcinoma.
Church C, Pulliam T, Longino N, Park SY, Smythe KS, Makarov V, Riaz N, Jing L, Amezquita R, Campbell JS, Gottardo R, Pierce RH, Choi J, Chan TA, Koelle DM, Nghiem P. Church C, et al. J Immunother Cancer. 2022 Sep;10(9):e005328. doi: 10.1136/jitc-2022-005328. J Immunother Cancer. 2022. PMID: 36252564 Free PMC article.
Tumor-Infiltrating Merkel Cell Polyomavirus-Specific T Cells Are Diverse and Associated with Improved Patient Survival.
Miller NJ, Church CD, Dong L, Crispin D, Fitzgibbon MP, Lachance K, Jing L, Shinohara M, Gavvovidis I, Willimsky G, McIntosh M, Blankenstein T, Koelle DM, Nghiem P. Miller NJ, et al. Cancer Immunol Res. 2017 Feb;5(2):137-147. doi: 10.1158/2326-6066.CIR-16-0210. Epub 2017 Jan 16. Cancer Immunol Res. 2017. PMID: 28093446 Free PMC article.
Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA.
Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio M, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG. Paulson KG, et al. Among authors: church cd. Nat Commun. 2018 Sep 24;9(1):3868. doi: 10.1038/s41467-018-06300-3. Nat Commun. 2018. PMID: 30250229 Free PMC article.
Multidimensional, quantitative assessment of PD-1/PD-L1 expression in patients with Merkel cell carcinoma and association with response to pembrolizumab.
Giraldo NA, Nguyen P, Engle EL, Kaunitz GJ, Cottrell TR, Berry S, Green B, Soni A, Cuda JD, Stein JE, Sunshine JC, Succaria F, Xu H, Ogurtsova A, Danilova L, Church CD, Miller NJ, Fling S, Lundgren L, Ramchurren N, Yearley JH, Lipson EJ, Cheever M, Anders RA, Nghiem PT, Topalian SL, Taube JM. Giraldo NA, et al. Among authors: church cd. J Immunother Cancer. 2018 Oct 1;6(1):99. doi: 10.1186/s40425-018-0404-0. J Immunother Cancer. 2018. PMID: 30285852 Free PMC article.
T cell receptor fingerprinting enables in-depth characterization of the interactions governing recognition of peptide-MHC complexes.
Bentzen AK, Such L, Jensen KK, Marquard AM, Jessen LE, Miller NJ, Church CD, Lyngaa R, Koelle DM, Becker JC, Linnemann C, Schumacher TNM, Marcatili P, Nghiem P, Nielsen M, Hadrup SR. Bentzen AK, et al. Among authors: church cd. Nat Biotechnol. 2018 Nov 19:10.1038/nbt.4303. doi: 10.1038/nbt.4303. Online ahead of print. Nat Biotechnol. 2018. PMID: 30451992 Free PMC article.
Durable Tumor Regression and Overall Survival in Patients With Advanced Merkel Cell Carcinoma Receiving Pembrolizumab as First-Line Therapy.
Nghiem P, Bhatia S, Lipson EJ, Sharfman WH, Kudchadkar RR, Brohl AS, Friedlander PA, Daud A, Kluger HM, Reddy SA, Boulmay BC, Riker AI, Burgess MA, Hanks BA, Olencki T, Margolin K, Lundgren LM, Soni A, Ramchurren N, Church C, Park SY, Shinohara MM, Salim B, Taube JM, Bird SR, Ibrahim N, Fling SP, Homet Moreno B, Sharon E, Cheever MA, Topalian SL. Nghiem P, et al. Among authors: church c. J Clin Oncol. 2019 Mar 20;37(9):693-702. doi: 10.1200/JCO.18.01896. Epub 2019 Feb 6. J Clin Oncol. 2019. PMID: 30726175 Free PMC article. Clinical Trial.
Human CD4+ T Cells Specific for Merkel Cell Polyomavirus Localize to Merkel Cell Carcinomas and Target a Required Oncogenic Domain.
Longino NV, Yang J, Iyer JG, Ibrani D, Chow IT, Laing KJ, Campbell VL, Paulson KG, Kulikauskas RM, Church CD, James EA, Nghiem P, Kwok WW, Koelle DM. Longino NV, et al. Cancer Immunol Res. 2019 Oct;7(10):1727-1739. doi: 10.1158/2326-6066.CIR-19-0103. Epub 2019 Aug 12. Cancer Immunol Res. 2019. PMID: 31405946 Free PMC article.
Prevalent and Diverse Intratumoral Oncoprotein-Specific CD8+ T Cells within Polyomavirus-Driven Merkel Cell Carcinomas.
Jing L, Ott M, Church CD, Kulikauskas RM, Ibrani D, Iyer JG, Afanasiev OK, Colunga A, Cook MM, Xie H, Greninger AL, Paulson KG, Chapuis AG, Bhatia S, Nghiem P, Koelle DM. Jing L, et al. Cancer Immunol Res. 2020 May;8(5):648-659. doi: 10.1158/2326-6066.CIR-19-0647. Epub 2020 Mar 16. Cancer Immunol Res. 2020. PMID: 32179557 Free PMC article.
385 results