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TGM2-mediated histone transglutamination is dictated by steric accessibility.
Lukasak BJ, Mitchener MM, Kong L, Dul BE, Lazarus CD, Ramakrishnan A, Ni J, Shen L, Maze I, Muir TW. Lukasak BJ, et al. Among authors: muir tw. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2208672119. doi: 10.1073/pnas.2208672119. Epub 2022 Oct 18. Proc Natl Acad Sci U S A. 2022. PMID: 36256821 Free PMC article.
H3R42me2a is a histone modification with positive transcriptional effects.
Casadio F, Lu X, Pollock SB, LeRoy G, Garcia BA, Muir TW, Roeder RG, Allis CD. Casadio F, et al. Among authors: muir tw. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14894-9. doi: 10.1073/pnas.1312925110. Epub 2013 Aug 26. Proc Natl Acad Sci U S A. 2013. PMID: 23980157 Free PMC article.
Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.
Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H 3rd, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I. Farrelly LA, et al. Among authors: muir tw. Nature. 2019 Mar;567(7749):535-539. doi: 10.1038/s41586-019-1024-7. Epub 2019 Mar 13. Nature. 2019. PMID: 30867594 Free PMC article.
PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor.
Diehl KL, Ge EJ, Weinberg DN, Jani KS, Allis CD, Muir TW. Diehl KL, et al. Among authors: muir tw. Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22152-22157. doi: 10.1073/pnas.1911775116. Epub 2019 Oct 14. Proc Natl Acad Sci U S A. 2019. PMID: 31611394 Free PMC article.
Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout.
Zhao S, Chuh KN, Zhang B, Dul BE, Thompson RE, Farrelly LA, Liu X, Xu N, Xue Y, Roeder RG, Maze I, Muir TW, Li H. Zhao S, et al. Among authors: muir tw. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2016742118. doi: 10.1073/pnas.2016742118. Proc Natl Acad Sci U S A. 2021. PMID: 33526675 Free PMC article.
257 results