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From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity.
Abdel-Halim M, Sigler S, Racheed NAS, Hefnawy A, Fathalla RK, Hammam MA, Maher A, Maxuitenko Y, Keeton AB, Hartmann RW, Engel M, Piazza GA, Abadi AH. Abdel-Halim M, et al. Among authors: fathalla rk. J Med Chem. 2021 Apr 22;64(8):4462-4477. doi: 10.1021/acs.jmedchem.0c01120. Epub 2021 Apr 1. J Med Chem. 2021. PMID: 33793216
A novel phosphodiesterase 5 inhibitor, RF26, improves memory impairment and ameliorates tau aggregation and neuroinflammation in the P301S tauopathy mouse model of Alzheimer's disease.
El-Desouky S, Abdel-Halim M, Fathalla RK, Abadi AH, Piazza GA, Salama M, El-Khodery SA, Youssef MA, Elfarrash S. El-Desouky S, et al. Among authors: fathalla rk. Exp Neurol. 2025 Feb;384:115058. doi: 10.1016/j.expneurol.2024.115058. Epub 2024 Nov 14. Exp Neurol. 2025. PMID: 39549949
Novel Celecoxib Derivative, RF26, Blocks Colon Cancer Cell Growth by Inhibiting PDE5, Activating cGMP/PKG Signaling, and Suppressing β-catenin-dependent Transcription.
Sigler S, Abdel-Halim M, Fathalla RK, Da Silva LM, Keeton AB, Maxuitenko YY, Berry K, Zhou G, Engel M, Abadi AH, Piazza GA. Sigler S, et al. Among authors: fathalla rk. Anticancer Agents Med Chem. 2024 Sep 2. doi: 10.2174/0118715206318802240821114353. Online ahead of print. Anticancer Agents Med Chem. 2024. PMID: 39225209