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A twenty-year journey exploring coumarin-based derivatives as bioactive molecules.
Pisani L, Catto M, Muncipinto G, Nicolotti O, Carrieri A, Rullo M, Stefanachi A, Leonetti F, Altomare C. Pisani L, et al. Among authors: muncipinto g. Front Chem. 2022 Oct 10;10:1002547. doi: 10.3389/fchem.2022.1002547. eCollection 2022. Front Chem. 2022. PMID: 36300022 Free PMC article. Review.
Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor.
Pisani L, Muncipinto G, Miscioscia TF, Nicolotti O, Leonetti F, Catto M, Caccia C, Salvati P, Soto-Otero R, Mendez-Alvarez E, Passeleu C, Carotti A. Pisani L, et al. Among authors: muncipinto g. J Med Chem. 2009 Nov 12;52(21):6685-706. doi: 10.1021/jm9010127. J Med Chem. 2009. PMID: 19810674
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.
Farina R, Pisani L, Catto M, Nicolotti O, Gadaleta D, Denora N, Soto-Otero R, Mendez-Alvarez E, Passos CS, Muncipinto G, Altomare CD, Nurisso A, Carrupt PA, Carotti A. Farina R, et al. Among authors: muncipinto g. J Med Chem. 2015 Jul 23;58(14):5561-78. doi: 10.1021/acs.jmedchem.5b00599. Epub 2015 Jul 9. J Med Chem. 2015. PMID: 26107513
Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents.
Comer E, Beaudoin JA, Kato N, Fitzgerald ME, Heidebrecht RW, Lee Md 4th, Masi D, Mercier M, Mulrooney C, Muncipinto G, Rowley A, Crespo-Llado K, Serrano AE, Lukens AK, Wiegand RC, Wirth DF, Palmer MA, Foley MA, Munoz B, Scherer CA, Duvall JR, Schreiber SL. Comer E, et al. Among authors: muncipinto g. J Med Chem. 2014 Oct 23;57(20):8496-502. doi: 10.1021/jm500994n. Epub 2014 Oct 13. J Med Chem. 2014. PMID: 25211597 Free PMC article.
Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease.
Dandapani S, Germain AR, Jewett I, le Quement S, Marie JC, Muncipinto G, Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J, Kellar D, Siqueira-Neto JL, McKerrow JH, Kaiser M, Rodriguez A, Palmer MA, Foley M, Schreiber SL, Munoz B. Dandapani S, et al. Among authors: muncipinto g. ACS Med Chem Lett. 2013 Dec 29;5(2):149-53. doi: 10.1021/ml400403u. eCollection 2014 Feb 13. ACS Med Chem Lett. 2013. PMID: 24900788 Free PMC article.
20 results