Song X - Search Results

1

1-Methyl-3-((4-(quinolin-4-yloxy)phenyl)amino)-1H-pyrazole-4-carboxamide derivatives as new rearranged during Transfection (RET) kinase inhibitors capable of suppressing resistant mutants in solvent-front regions.

Zhang Y, Chan S, He R, Liu Y, Song X, Tu ZC, Ren X, Zhou Y, Zhang Z, Wang Z, Zhou F, Ding K. Zhang Y, et al. Among authors: song x. Eur J Med Chem. 2022 Dec 15;244:114862. doi: 10.1016/j.ejmech.2022.114862. Epub 2022 Oct 21. Eur J Med Chem. 2022. PMID: 36308779

2

Investigation of Covalent Warheads in the Design of 2-Aminopyrimidine-based FGFR4 Inhibitors.

Deng W, Chen X, Jiang K, Song X, Huang M, Tu ZC, Zhang Z, Lin X, Ortega R, Patterson AV, Smaill JB, Ding K, Chen S, Chen Y, Lu X. Deng W, et al. Among authors: song x. ACS Med Chem Lett. 2021 Mar 22;12(4):647-652. doi: 10.1021/acsmedchemlett.1c00052. eCollection 2021 Apr 8. ACS Med Chem Lett. 2021. PMID: 33859803 Free PMC article.

3

GZD824 overcomes FGFR1-V561F/M mutant resistance in vitro and in vivo.

Jiang K, Tang X, Guo J, He R, Chan S, Song X, Tu Z, Wang Y, Ren X, Ding K, Zhang Z. Jiang K, et al. Among authors: song x. Cancer Med. 2021 Jul;10(14):4874-4884. doi: 10.1002/cam4.4041. Epub 2021 Jun 10. Cancer Med. 2021. PMID: 34114373 Free PMC article.

4

Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design.

Zhang Z, Wang Y, Chen X, Song X, Tu Z, Chen Y, Zhang Z, Ding K. Zhang Z, et al. Among authors: song x. Bioorg Med Chem. 2021 Nov 15;50:116457. doi: 10.1016/j.bmc.2021.116457. Epub 2021 Oct 5. Bioorg Med Chem. 2021. PMID: 34670167

5

Identification of U937^JAK3-M511I Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor.

Si H, Wang J, He R, Yu X, Li S, Huang J, Li J, Tang X, Song X, Tu Z, Zhang Z, Ding K. Si H, et al. Among authors: song x. Front Oncol. 2022 Jan 17;11:807200. doi: 10.3389/fonc.2021.807200. eCollection 2021. Front Oncol. 2022. PMID: 35111683 Free PMC article.

6

Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors.

Zhang Z, Li J, Chen H, Huang J, Song X, Tu ZC, Zhang Z, Peng L, Zhou Y, Ding K. Zhang Z, et al. Among authors: song x. J Med Chem. 2022 Feb 24;65(4):3249-3265. doi: 10.1021/acs.jmedchem.1c01816. Epub 2022 Feb 4. J Med Chem. 2022. PMID: 35119278

7

Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.

Shao M, Chen X, Yang F, Song X, Zhou Y, Lin Q, Fu Y, Ortega R, Lin X, Tu Z, Patterson AV, Smaill JB, Chen Y, Lu X. Shao M, et al. Among authors: song x. J Med Chem. 2022 Mar 24;65(6):5113-5133. doi: 10.1021/acs.jmedchem.2c00096. Epub 2022 Mar 10. J Med Chem. 2022. PMID: 35271262

8

Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance.

Wang Z, Wang J, Wang Y, Xiang S, Song X, Tu Z, Zhou Y, Zhang ZM, Zhang Z, Ding K, Lu X. Wang Z, et al. Among authors: song x. J Med Chem. 2022 Apr 28;65(8):6325-6337. doi: 10.1021/acs.jmedchem.2c00308. Epub 2022 Apr 15. J Med Chem. 2022. PMID: 35426680

9

Discovery of Hexahydrofuro[3,2-b]furans as New Kinase-Selective and Orally Bioavailable JAK3 Inhibitors for the Treatment of Leukemia Harboring a JAK3 Activating Mutant.

Li S, Si H, Song X, Lei C, He X, Wang J, Liu Y, Zhou Y, Song JG, Peng L, Tang X, Chan S, Ren X, Tu Z, Li Z, Wang Z, Zhang Z, Ding K. Li S, et al. Among authors: song x, song jg. J Med Chem. 2022 Aug 11;65(15):10674-10690. doi: 10.1021/acs.jmedchem.2c00922. Epub 2022 Jul 20. J Med Chem. 2022. PMID: 35860875

10

JND4135, a New Type II TRK Inhibitor, Overcomes TRK xDFG and Other Mutation Resistance In Vitro and In Vivo.

Wang J, Zhou Y, Tang X, Yu X, Wang Y, Chan S, Song X, Tu Z, Zhang Z, Lu X, Zhang Z, Ding K. Wang J, et al. Among authors: song x. Molecules. 2022 Oct 1;27(19):6500. doi: 10.3390/molecules27196500. Molecules. 2022. PMID: 36235036 Free PMC article.

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