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Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance.
Gulen MF, Bulek K, Xiao H, Yu M, Gao J, Sun L, Beurel E, Kaidanovich-Beilin O, Fox PL, DiCorleto PE, Wang JA, Qin J, Wald DN, Woodgett JR, Jope RS, Carman J, Dongre A, Li X. Gulen MF, et al. Among authors: fox pl. Immunity. 2012 Nov 16;37(5):800-12. doi: 10.1016/j.immuni.2012.08.019. Epub 2012 Nov 8. Immunity. 2012. PMID: 23142783 Free PMC article.
IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling.
Herjan T, Hong L, Bubenik J, Bulek K, Qian W, Liu C, Li X, Chen X, Yang H, Ouyang S, Zhou H, Zhao J, Vasu K, Cockman E, Aronica M, Asosingh K, Licatalosi DD, Qin J, Fox PL, Hamilton TA, Driscoll D, Li X. Herjan T, et al. Among authors: fox pl. Nat Immunol. 2018 Apr;19(4):354-365. doi: 10.1038/s41590-018-0071-9. Epub 2018 Mar 21. Nat Immunol. 2018. PMID: 29563620 Free PMC article.
Aminoacyl-tRNA synthetases as therapeutic targets.
Kwon NH, Fox PL, Kim S. Kwon NH, et al. Among authors: fox pl. Nat Rev Drug Discov. 2019 Aug;18(8):629-650. doi: 10.1038/s41573-019-0026-3. Nat Rev Drug Discov. 2019. PMID: 31073243 Review.
A viral pan-end RNA element and host complex define a SARS-CoV-2 regulon.
Khan D, Terenzi F, Liu G, Ghosh PK, Ye F, Nguyen K, China A, Ramachandiran I, Chakraborty S, Stefan J, Khan K, Vasu K, Dong F, Willard B, Karn J, Gack MU, Fox PL. Khan D, et al. Among authors: fox pl. Nat Commun. 2023 Jun 9;14(1):3385. doi: 10.1038/s41467-023-39091-3. Nat Commun. 2023. PMID: 37296097 Free PMC article.
Homozygous EPRS1 missense variant causing hypomyelinating leukodystrophy-15 alters variant-distal mRNA m6A site accessibility.
Khan D, Ramachandiran I, Vasu K, China A, Khan K, Cumbo F, Halawani D, Terenzi F, Zin I, Long B, Costain G, Blaser S, Carnevale A, Gogonea V, Dutta R, Blankenberg D, Yoon G, Fox PL. Khan D, et al. Among authors: fox pl. Nat Commun. 2024 May 20;15(1):4284. doi: 10.1038/s41467-024-48549-x. Nat Commun. 2024. PMID: 38769304 Free PMC article.
AKT-dependent nuclear localization of EPRS1 activates PARP1 in breast cancer cells.
Zin I, China A, Khan K, Nag JK, Vasu K, Deshpande GM, Ghosh PK, Khan D, Ramachandiran I, Ganguly S, Tamagno I, Willard B, Gogonea V, Fox PL. Zin I, et al. Among authors: fox pl. Proc Natl Acad Sci U S A. 2024 Jul 23;121(30):e2303642121. doi: 10.1073/pnas.2303642121. Epub 2024 Jul 16. Proc Natl Acad Sci U S A. 2024. PMID: 39012819 Free PMC article.
182 results