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Increased intracellular Cl- concentration promotes ongoing inflammation in airway epithelium.
Zhang YL, Chen PX, Guan WJ, Guo HM, Qiu ZE, Xu JW, Luo YL, Lan CF, Xu JB, Hao Y, Tan YX, Ye KN, Lun ZR, Zhao L, Zhu YX, Huang J, Ko WH, Zhong WD, Zhou WL, Zhong NS. Zhang YL, et al. Among authors: guan wj. Mucosal Immunol. 2018 Jul;11(4):1149-1157. doi: 10.1038/s41385-018-0013-8. Epub 2018 Mar 15. Mucosal Immunol. 2018. PMID: 29545647 Free article.
SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl- accumulation in respiratory epithelium.
Chen L, Guan WJ, Qiu ZE, Xu JB, Bai X, Hou XC, Sun J, Qu S, Huang ZX, Lei TL, Huang ZY, Zhao J, Zhu YX, Ye KN, Lun ZR, Zhou WL, Zhong NS, Zhang YL. Chen L, et al. Among authors: guan wj. Signal Transduct Target Ther. 2022 Jul 27;7(1):255. doi: 10.1038/s41392-022-01048-1. Signal Transduct Target Ther. 2022. PMID: 35896532 Free PMC article.
SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl- concentration.
Xu JB, Guan WJ, Zhang YL, Qiu ZE, Chen L, Hou XC, Yue J, Zhou YY, Sheng J, Zhao L, Zhu YX, Sun J, Zhao J, Zhou WL, Zhong NS. Xu JB, et al. Among authors: guan wj. Signal Transduct Target Ther. 2024 Mar 25;9(1):74. doi: 10.1038/s41392-024-01753-z. Signal Transduct Target Ther. 2024. PMID: 38528022 Free PMC article.
272 results