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Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders.
El Andari J, Renaud-Gabardos E, Tulalamba W, Weinmann J, Mangin L, Pham QH, Hille S, Bennett A, Attebi E, Bourges E, Leborgne C, Guerchet N, Fakhiri J, Krämer C, Wiedtke E, McKenna R, Guianvarc'h L, Toueille M, Ronzitti G, Hebben M, Mingozzi F, VandenDriessche T, Agbandje-McKenna M, Müller OJ, Chuah MK, Buj-Bello A, Grimm D. El Andari J, et al. Among authors: wiedtke e. Sci Adv. 2022 Sep 23;8(38):eabn4704. doi: 10.1126/sciadv.abn4704. Epub 2022 Sep 21. Sci Adv. 2022. PMID: 36129972 Free PMC article.
A Robust and All-Inclusive Pipeline for Shuffling of Adeno-Associated Viruses.
Herrmann AK, Bender C, Kienle E, Grosse S, El Andari J, Botta J, Schürmann N, Wiedtke E, Niopek D, Grimm D. Herrmann AK, et al. Among authors: wiedtke e. ACS Synth Biol. 2019 Jan 18;8(1):194-206. doi: 10.1021/acssynbio.8b00373. Epub 2019 Jan 8. ACS Synth Biol. 2019. PMID: 30513195
Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening.
Börner K, Kienle E, Huang LY, Weinmann J, Sacher A, Bayer P, Stüllein C, Fakhiri J, Zimmermann L, Westhaus A, Beneke J, Beil N, Wiedtke E, Schmelas C, Miltner D, Rau A, Erfle H, Kräusslich HG, Müller M, Agbandje-McKenna M, Grimm D. Börner K, et al. Among authors: wiedtke e. Mol Ther. 2020 Apr 8;28(4):1016-1032. doi: 10.1016/j.ymthe.2020.02.009. Epub 2020 Feb 13. Mol Ther. 2020. PMID: 32105604 Free PMC article.
Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening.
Flitsch LJ, Börner K, Stüllein C, Ziegler S, Sonntag-Buck V, Wiedtke E, Semkova V, Au Yeung SWC, Schlee J, Hajo M, Mathews M, Ludwig BS, Kossatz S, Kessler H, Grimm D, Brüstle O. Flitsch LJ, et al. Among authors: wiedtke e. Sci Rep. 2022 May 19;12(1):8356. doi: 10.1038/s41598-022-12404-0. Sci Rep. 2022. PMID: 35589936 Free PMC article.
18 results