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N-Methyl-(2S, 4R)-trans-4-hydroxy-L-proline, the major bioactive compound from Sideroxylon obtusifolium, attenuates pilocarpine-induced injury in cultured astrocytes.
Aquino PEA, Siqueira EA, Paes LCF, Magalhães EP, Barbosa TM, Carvalho MAJ, Azul FVCS, Lustosa IR, Mottin M, Sampaio TL, Martins AMC, Silveira ER, Viana GSB. Aquino PEA, et al. Among authors: mottin m. Braz J Med Biol Res. 2022 Nov 4;55:e12381. doi: 10.1590/1414-431X2022e12381. eCollection 2022. Braz J Med Biol Res. 2022. PMID: 36350974 Free PMC article.
Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate.
Freire MCLC, Basso LGM, Mendes LFS, Mesquita NCMR, Mottin M, Fernandes RS, Policastro LR, Godoy AS, Santos IA, Ruiz UEA, Caruso IP, Sousa BKP, Jardim ACG, Almeida FCL, Gil LHVG, Andrade CH, Oliva G. Freire MCLC, et al. Among authors: mottin m. Sci Rep. 2022 Jun 22;12(1):10601. doi: 10.1038/s41598-022-14790-x. Sci Rep. 2022. PMID: 35732685 Free PMC article.
High Throughput and Computational Repurposing for Neglected Diseases.
Hernandez HW, Soeung M, Zorn KM, Ashoura N, Mottin M, Andrade CH, Caffrey CR, de Siqueira-Neto JL, Ekins S. Hernandez HW, et al. Among authors: mottin m. Pharm Res. 2018 Dec 17;36(2):27. doi: 10.1007/s11095-018-2558-3. Pharm Res. 2018. PMID: 30560386 Free PMC article. Review.
The A-Z of Zika drug discovery.
Mottin M, Borba JVVB, Braga RC, Torres PHM, Martini MC, Proenca-Modena JL, Judice CC, Costa FTM, Ekins S, Perryman AL, Horta Andrade C. Mottin M, et al. Drug Discov Today. 2018 Nov;23(11):1833-1847. doi: 10.1016/j.drudis.2018.06.014. Epub 2018 Jun 20. Drug Discov Today. 2018. PMID: 29935345 Free PMC article. Review.
A Proline Derivative-Enriched Fraction from Sideroxylon obtusifolium Protects the Hippocampus from Intracerebroventricular Pilocarpine-Induced Injury Associated with Status Epilepticus in Mice.
de Aquino PEA, Rabelo Bezerra J, de Souza Nascimento T, Tavares J, Rosal Lustosa Í, Chaves Filho AJM, Mottin M, Macêdo Gaspar D, Andrade GM, Tavares Neves KR, Biagini G, Silveira ER, de Barros Viana GS. de Aquino PEA, et al. Among authors: mottin m. Int J Mol Sci. 2020 Jun 11;21(11):4188. doi: 10.3390/ijms21114188. Int J Mol Sci. 2020. PMID: 32545390 Free PMC article.
Neuroprotective effects of dimethyl fumarate against depression-like behaviors via astrocytes and microglia modulation in mice: possible involvement of the HCAR2/Nrf2 signaling pathway.
de Souza AG, Lopes IS, Filho AJMC, Cavalcante TMB, Oliveira JVS, de Carvalho MAJ, de Lima KA, Jucá PM, Mendonça SS, Mottin M, Andrade CH, de Sousa FCF, Macedo DS, de França Fonteles MM. de Souza AG, et al. Among authors: mottin m. Naunyn Schmiedebergs Arch Pharmacol. 2022 Sep;395(9):1029-1045. doi: 10.1007/s00210-022-02247-x. Epub 2022 Jun 4. Naunyn Schmiedebergs Arch Pharmacol. 2022. PMID: 35665831
GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain.
Amato AA, Rajagopalan S, Lin JZ, Carvalho BM, Figueira AC, Lu J, Ayers SD, Mottin M, Silveira RL, Souza PC, Mourão RH, Saad MJ, Togashi M, Simeoni LA, Abdalla DS, Skaf MS, Polikparpov I, Lima MC, Galdino SL, Brennan RG, Baxter JD, Pitta IR, Webb P, Phillips KJ, Neves FA. Amato AA, et al. Among authors: mottin m. J Biol Chem. 2012 Aug 10;287(33):28169-79. doi: 10.1074/jbc.M111.332106. Epub 2012 May 14. J Biol Chem. 2012. PMID: 22584573 Free PMC article.
34 results