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AAV-mediated neuronal expression of an scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models.
Selles MC, Fortuna JTS, Cercato MC, Santos LE, Domett L, Bitencourt ALB, Carraro MF, Souza AS, Janickova H, Azevedo CV, Campos HC, de Souza JM, Alves-Leon S, Prado VF, Prado MAM, Epstein AL, Salvetti A, Longo BM, Arancio O, Klein WL, Sebollela A, De Felice FG, Jerusalinsky DA, Ferreira ST. Selles MC, et al. Among authors: sebollela a. Mol Ther. 2023 Feb 1;31(2):409-419. doi: 10.1016/j.ymthe.2022.11.002. Epub 2022 Nov 11. Mol Ther. 2023. PMID: 36369741 Free PMC article.
Heparin-binding sites in granulocyte-macrophage colony-stimulating factor. Localization and regulation by histidine ionization.
Sebollela A, Cagliari TC, Limaverde GS, Chapeaurouge A, Sorgine MH, Coelho-Sampaio T, Ramos CH, Ferreira ST. Sebollela A, et al. J Biol Chem. 2005 Sep 9;280(36):31949-56. doi: 10.1074/jbc.M505314200. Epub 2005 Jul 15. J Biol Chem. 2005. PMID: 16027123 Free article.
We have proposed previously that helix C, one of the four alpha-helices of human GM-CSF (hGM-CSF), contains a GAG-binding site in which positively charged residues are spatially positioned for interaction with the sulfate moieties of the GAGs (Wettreich, A., Sebo …
We have proposed previously that helix C, one of the four alpha-helices of human GM-CSF (hGM-CSF), contains a GAG-binding site in whi …
Expression profile of rat hippocampal neurons treated with the neuroprotective compound 2,4-dinitrophenol: up-regulation of cAMP signaling genes.
Sebollela A, Freitas-Corrêa L, Oliveira FF, Mendes CT, Wasilewska-Sampaio AP, Camacho-Pereira J, Galina A, Brentani H, Passetti F, De Felice FG, Dias-Neto E, Ferreira ST. Sebollela A, et al. Neurotox Res. 2010 Aug;18(2):112-23. doi: 10.1007/s12640-009-9133-y. Epub 2009 Dec 1. Neurotox Res. 2010. PMID: 19949915
Amyloid β-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in hippocampal neurons and prevent RyR-mediated dendritic spine remodeling produced by BDNF.
Paula-Lima AC, Adasme T, SanMartín C, Sebollela A, Hetz C, Carrasco MA, Ferreira ST, Hidalgo C. Paula-Lima AC, et al. Among authors: sebollela a. Antioxid Redox Signal. 2011 Apr 1;14(7):1209-23. doi: 10.1089/ars.2010.3287. Epub 2011 Jan 6. Antioxid Redox Signal. 2011. PMID: 20712397
Amyloid-β oligomers induce differential gene expression in adult human brain slices.
Sebollela A, Freitas-Correa L, Oliveira FF, Paula-Lima AC, Saraiva LM, Martins SM, Mota LD, Torres C, Alves-Leon S, de Souza JM, Carraro DM, Brentani H, De Felice FG, Ferreira ST. Sebollela A, et al. J Biol Chem. 2012 Mar 2;287(10):7436-45. doi: 10.1074/jbc.M111.298471. Epub 2012 Jan 10. J Biol Chem. 2012. PMID: 22235132 Free PMC article. Clinical Trial.
27 results