May LT - Search Results

1

Publisher Correction to: Adenosine receptor signalling in Alzheimer's disease.

Trinh PNH, Baltos JA, Hellyer SD, May LT, Gregory KJ. Trinh PNH, et al. Among authors: may lt. Purinergic Signal. 2022 Dec;18(4):407. doi: 10.1007/s11302-022-09906-x. Purinergic Signal. 2022. PMID: 36383276 Free PMC article. No abstract available.

2

Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist.

Valant C, May LT, Aurelio L, Chuo CH, White PJ, Baltos JA, Sexton PM, Scammells PJ, Christopoulos A. Valant C, et al. Among authors: may lt. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4614-9. doi: 10.1073/pnas.1320962111. Epub 2014 Mar 11. Proc Natl Acad Sci U S A. 2014. PMID: 24619092 Free PMC article.

3

Quantification of adenosine A(1) receptor biased agonism: Implications for drug discovery.

Baltos JA, Gregory KJ, White PJ, Sexton PM, Christopoulos A, May LT. Baltos JA, et al. Among authors: may lt. Biochem Pharmacol. 2016 Jan 1;99:101-12. doi: 10.1016/j.bcp.2015.11.013. Epub 2015 Nov 12. Biochem Pharmacol. 2016. PMID: 26581123

4

Ligand-Independent Adenosine A2B Receptor Constitutive Activity as a Promoter of Prostate Cancer Cell Proliferation.

Vecchio EA, Tan CY, Gregory KJ, Christopoulos A, White PJ, May LT. Vecchio EA, et al. Among authors: may lt. J Pharmacol Exp Ther. 2016 Apr;357(1):36-44. doi: 10.1124/jpet.115.230003. Epub 2016 Jan 20. J Pharmacol Exp Ther. 2016. PMID: 26791603

5

Structure-Activity Analysis of Biased Agonism at the Human Adenosine A3 Receptor.

Baltos JA, Paoletta S, Nguyen AT, Gregory KJ, Tosh DK, Christopoulos A, Jacobson KA, May LT. Baltos JA, et al. Among authors: may lt. Mol Pharmacol. 2016 Jul;90(1):12-22. doi: 10.1124/mol.116.103283. Epub 2016 May 2. Mol Pharmacol. 2016. PMID: 27136943 Free PMC article.

6

The hybrid molecule, VCP746, is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling.

Vecchio EA, Chuo CH, Baltos JA, Ford L, Scammells PJ, Wang BH, Christopoulos A, White PJ, May LT. Vecchio EA, et al. Among authors: may lt. Biochem Pharmacol. 2016 Oct 1;117:46-56. doi: 10.1016/j.bcp.2016.08.007. Epub 2016 Aug 9. Biochem Pharmacol. 2016. PMID: 27520486

7

Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity.

Nguyen AT, Vecchio EA, Thomas T, Nguyen TD, Aurelio L, Scammells PJ, White PJ, Sexton PM, Gregory KJ, May LT, Christopoulos A. Nguyen AT, et al. Among authors: may lt. Mol Pharmacol. 2016 Dec;90(6):715-725. doi: 10.1124/mol.116.105015. Epub 2016 Sep 28. Mol Pharmacol. 2016. PMID: 27683013

8

Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy.

Nguyen AT, Baltos JA, Thomas T, Nguyen TD, Muñoz LL, Gregory KJ, White PJ, Sexton PM, Christopoulos A, May LT. Nguyen AT, et al. Among authors: may lt. Mol Pharmacol. 2016 Dec;90(6):703-714. doi: 10.1124/mol.116.105007. Epub 2016 Sep 28. Mol Pharmacol. 2016. PMID: 27683014

9

Capadenoson, a clinically trialed partial adenosine A₁ receptor agonist, can stimulate adenosine A_2B receptor biased agonism.

Baltos JA, Vecchio EA, Harris MA, Qin CX, Ritchie RH, Christopoulos A, White PJ, May LT. Baltos JA, et al. Among authors: may lt. Biochem Pharmacol. 2017 Jul 1;135:79-89. doi: 10.1016/j.bcp.2017.03.014. Epub 2017 Mar 23. Biochem Pharmacol. 2017. PMID: 28344125

10

α_1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes.

Sato M, Evans BA, Sandström AL, Chia LY, Mukaida S, Thai BS, Nguyen A, Lim L, Tan CYR, Baltos JA, White PJ, May LT, Hutchinson DS, Summers RJ, Bengtsson T. Sato M, et al. Among authors: may lt. Biochem Pharmacol. 2018 Feb;148:27-40. doi: 10.1016/j.bcp.2017.11.016. Epub 2017 Nov 24. Biochem Pharmacol. 2018. PMID: 29175420 Free article.

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