Disney MD - Search Results

1

Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion.

Gibaut QMR, Akahori Y, Bush JA, Taghavi A, Tanaka T, Aikawa H, Ryan LS, Paegel BM, Disney MD. Gibaut QMR, et al. Among authors: disney md. J Am Chem Soc. 2022 Dec 7;144(48):21972-21979. doi: 10.1021/jacs.2c08883. Epub 2022 Nov 18. J Am Chem Soc. 2022. PMID: 36399603 Free PMC article.

2

Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching.

Parkesh R, Childs-Disney JL, Nakamori M, Kumar A, Wang E, Wang T, Hoskins J, Tran T, Housman D, Thornton CA, Disney MD. Parkesh R, et al. Among authors: disney md. J Am Chem Soc. 2012 Mar 14;134(10):4731-42. doi: 10.1021/ja210088v. Epub 2012 Mar 5. J Am Chem Soc. 2012. PMID: 22300544 Free PMC article.

3

Rational design of bioactive, modularly assembled aminoglycosides targeting the RNA that causes myotonic dystrophy type 1.

Childs-Disney JL, Parkesh R, Nakamori M, Thornton CA, Disney MD. Childs-Disney JL, et al. Among authors: disney md. ACS Chem Biol. 2012 Dec 21;7(12):1984-93. doi: 10.1021/cb3001606. Epub 2012 Nov 7. ACS Chem Biol. 2012. PMID: 23130637 Free PMC article.

4

Inhibition of Non-ATG Translational Events in Cells via Covalent Small Molecules Targeting RNA.

Yang WY, Wilson HD, Velagapudi SP, Disney MD. Yang WY, et al. Among authors: disney md. J Am Chem Soc. 2015 Apr 29;137(16):5336-45. doi: 10.1021/ja507448y. Epub 2015 Apr 15. J Am Chem Soc. 2015. PMID: 25825793 Free PMC article.

5

Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy.

Rzuczek SG, Southern MR, Disney MD. Rzuczek SG, et al. Among authors: disney md. ACS Chem Biol. 2015 Dec 18;10(12):2706-15. doi: 10.1021/acschembio.5b00430. Epub 2015 Sep 28. ACS Chem Biol. 2015. PMID: 26414664 Free PMC article.

6

Precise small-molecule recognition of a toxic CUG RNA repeat expansion.

Rzuczek SG, Colgan LA, Nakai Y, Cameron MD, Furling D, Yasuda R, Disney MD. Rzuczek SG, et al. Among authors: disney md. Nat Chem Biol. 2017 Feb;13(2):188-193. doi: 10.1038/nchembio.2251. Epub 2016 Dec 12. Nat Chem Biol. 2017. PMID: 27941760 Free PMC article.

7

Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit.

Costales MG, Haga CL, Velagapudi SP, Childs-Disney JL, Phinney DG, Disney MD. Costales MG, et al. Among authors: disney md. J Am Chem Soc. 2017 Mar 8;139(9):3446-3455. doi: 10.1021/jacs.6b11273. Epub 2017 Feb 27. J Am Chem Soc. 2017. PMID: 28240549 Free PMC article.

8

Small Molecule Targeted Recruitment of a Nuclease to RNA.

Costales MG, Matsumoto Y, Velagapudi SP, Disney MD. Costales MG, et al. Among authors: disney md. J Am Chem Soc. 2018 Jun 6;140(22):6741-6744. doi: 10.1021/jacs.8b01233. Epub 2018 May 24. J Am Chem Soc. 2018. PMID: 29792692 Free PMC article.

9

A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin.

Costales MG, Hoch DG, Abegg D, Childs-Disney JL, Velagapudi SP, Adibekian A, Disney MD. Costales MG, et al. Among authors: disney md. J Am Chem Soc. 2019 Feb 20;141(7):2960-2974. doi: 10.1021/jacs.8b10558. Epub 2019 Feb 6. J Am Chem Soc. 2019. PMID: 30726072 Free PMC article.

10

Targeting RNA with Small Molecules To Capture Opportunities at the Intersection of Chemistry, Biology, and Medicine.

Disney MD. Disney MD. J Am Chem Soc. 2019 May 1;141(17):6776-6790. doi: 10.1021/jacs.8b13419. Epub 2019 Apr 19. J Am Chem Soc. 2019. PMID: 30896935 Free PMC article.

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