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Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier.
Faist A, Schloer S, Mecate-Zambrano A, Janowski J, Schreiber A, Boergeling Y, Conrad BCG, Kumar S, Toebben L, Schughart K, Baumgardt M, Kessler M, Hoenzke K, Hocke A, Trautmann M, Hartmann W, Kato H, Rescher U, Christersson A, Kuehn J, Mellmann A, Wolff T, Kuempers P, Rovas A, Wiewrodt R, Wiebe K, Barth P, Ludwig S, Brunotte L. Faist A, et al. Among authors: kuehn j. Antiviral Res. 2023 Jan;209:105475. doi: 10.1016/j.antiviral.2022.105475. Epub 2022 Nov 21. Antiviral Res. 2023. PMID: 36423831 Free PMC article.
Gut microbial metabolism in Alzheimer's disease and related dementias.
Kang JW, Vemuganti V, Kuehn JF, Ulland TK, Rey FE, Bendlin BB. Kang JW, et al. Among authors: kuehn jf. Neurotherapeutics. 2024 Oct;21(6):e00470. doi: 10.1016/j.neurot.2024.e00470. Epub 2024 Oct 28. Neurotherapeutics. 2024. PMID: 39462700 Free PMC article. Review.
Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors.
Kuehn JC, Metzger P, Neidert N, Matysiak U, Gräßel L, Philipp U, Bleul S, Pauli T, Falkenstein J, Bertemes H, Cysar S, Hess ME, Frey AV, Duque-Afonso J, Schorb E, Machein M, Beck J, Schnell O, von Bubnoff N, Illert AL, Peters C, Brummer T, Prinz M, Miething C, Becker H, Lassmann S, Werner M, Börries M, Duyster J, Heiland DH, Sankowski R, Scherer F. Kuehn JC, et al. NPJ Precis Oncol. 2024 Aug 14;8(1):180. doi: 10.1038/s41698-024-00674-y. NPJ Precis Oncol. 2024. PMID: 39143272 Free PMC article.
Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans.
Benz F, Camara-Wilpert S, Russel J, Wandera KG, Čepaitė R, Ares-Arroyo M, Gomes-Filho JV, Englert F, Kuehn JA, Gloor S, Mestre MR, Cuénod A, Aguilà-Sans M, Maccario L, Egli A, Randau L, Pausch P, Rocha EPC, Beisel CL, Madsen JS, Bikard D, Hall AR, Sørensen SJ, Pinilla-Redondo R. Benz F, et al. Among authors: kuehn ja. Cell Host Microbe. 2024 Jun 12;32(6):875-886.e9. doi: 10.1016/j.chom.2024.04.016. Epub 2024 May 15. Cell Host Microbe. 2024. PMID: 38754416
Surrogate Virus Neutralisation Test Based on Nanoluciferase-Tagged Antigens to Quantify Inhibitory Antibodies against SARS-CoV-2 and Characterise Omicron-Specific Reactivity in a Vaccination Cohort.
Schoefbaenker M, Neddermeyer R, Guenther T, Mueller MM, Romberg ML, Classen N, Hennies MT, Hrincius ER, Ludwig S, Kuehn JE, Lorentzen EU. Schoefbaenker M, et al. Among authors: kuehn je. Vaccines (Basel). 2023 Dec 8;11(12):1832. doi: 10.3390/vaccines11121832. Vaccines (Basel). 2023. PMID: 38140236 Free PMC article.
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