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Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Piel S, Janowska JI, Ward JL, McManus MJ, Jose JS, Starr J, Sheldon M, Clayman CL, Elmér E, Hansson MJ, Jang DH, Karlsson M, Ehinger JK, Kilbaugh TJ. Piel S, et al. Among authors: ehinger jk. Sci Rep. 2022 Nov 25;12(1):20329. doi: 10.1038/s41598-022-24472-3. Sci Rep. 2022. PMID: 36434021 Free PMC article.
Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency.
Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner EÅ, Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E. Ehinger JK, et al. Nat Commun. 2016 Aug 9;7:12317. doi: 10.1038/ncomms12317. Nat Commun. 2016. PMID: 27502960 Free PMC article.
37 results