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IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Gaggero S, Martinez-Fabregas J, Cozzani A, Fyfe PK, Leprohon M, Yang J, Thomasen FE, Winkelmann H, Magnez R, Conti AG, Wilmes S, Pohler E, van Gijsel Bonnello M, Thuru X, Quesnel B, Soncin F, Piehler J, Lindorff-Larsen K, Roychoudhuri R, Moraga I, Mitra S. Gaggero S, et al. Sci Immunol. 2022 Dec 9;7(78):eade5686. doi: 10.1126/sciimmunol.ade5686. Epub 2022 Dec 2. Sci Immunol. 2022. PMID: 36459543
Probabilistic Determination of Native State Ensembles of Proteins.
Olsson S, Vögeli BR, Cavalli A, Boomsma W, Ferkinghoff-Borg J, Lindorff-Larsen K, Hamelryck T. Olsson S, et al. J Chem Theory Comput. 2014 Aug 12;10(8):3484-91. doi: 10.1021/ct5001236. Epub 2014 Jun 30. J Chem Theory Comput. 2014. PMID: 26588313
Atomic-level description of ubiquitin folding.
Piana S, Lindorff-Larsen K, Shaw DE. Piana S, et al. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5915-20. doi: 10.1073/pnas.1218321110. Epub 2013 Mar 15. Proc Natl Acad Sci U S A. 2013. PMID: 23503848 Free PMC article.
Comparing molecular dynamics force fields in the essential subspace.
Martín-García F, Papaleo E, Gomez-Puertas P, Boomsma W, Lindorff-Larsen K. Martín-García F, et al. PLoS One. 2015 Mar 26;10(3):e0121114. doi: 10.1371/journal.pone.0121114. eCollection 2015. PLoS One. 2015. PMID: 25811178 Free PMC article.
249 results