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Bypassing evolutionary dead ends and switching the rate-limiting step of a human immunotherapeutic enzyme.
Blazeck J, Karamitros CS, Ford K, Somody C, Qerqez A, Murray K, Burkholder NT, Marshall N, Sivakumar A, Lu WC, Tan B, Lamb C, Tanno Y, Siddiqui MY, Ashoura N, Coma S, Zhang XM, McGovern K, Kumada Y, Zhang YJ, Manfredi M, Johnson KA, D'Arcy S, Stone E, Georgiou G. Blazeck J, et al. Among authors: georgiou g. Nat Catal. 2022 Oct;5(10):952-967. doi: 10.1038/s41929-022-00856-6. Epub 2022 Oct 19. Nat Catal. 2022. PMID: 36465553 Free PMC article.
Infant Antibody Repertoires during the First Two Years of Influenza Vaccination.
Kuraoka M, Curtis NC, Watanabe A, Tanno H, Shin S, Ye K, Macdonald E, Lavidor O, Kong S, Von Holle T, Windsor I, Ippolito GC, Georgiou G, Walter EB, Kelsoe G, Harrison SC, Moody MA, Bajic G, Lee J. Kuraoka M, et al. Among authors: georgiou g. mBio. 2022 Dec 20;13(6):e0254622. doi: 10.1128/mbio.02546-22. Epub 2022 Oct 31. mBio. 2022. PMID: 36314798 Free PMC article.
Mutability and hypermutation antagonize immunoglobulin codon optimality.
McGrath JJC, Park J, Troxell CA, Chervin JC, Li L, Kent JR, Changrob S, Fu Y, Huang M, Zheng NY, Wilbanks GD, Nelson SA, Sun J, Inghirami G, Madariaga MLL, Georgiou G, Wilson PC. McGrath JJC, et al. Among authors: georgiou g. Mol Cell. 2025 Jan 16;85(2):430-444.e6. doi: 10.1016/j.molcel.2024.11.033. Epub 2024 Dec 20. Mol Cell. 2025. PMID: 39708804
Adiponectin, resistin, interleukin-4 and TGF-β2 levels in treatment resistant schizophrenia patients.
Karampas A, Leontaritis G, Markozannes G, Asimakopoulos A, Archimandriti DT, Spyrou P, Georgiou G, Plakoutsis M, Kotsis K, Voulgari PV, Petrikis P. Karampas A, et al. Among authors: georgiou g. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Dec 17;136:111221. doi: 10.1016/j.pnpbp.2024.111221. Online ahead of print. Prog Neuropsychopharmacol Biol Psychiatry. 2024. PMID: 39701174
Molecular features of the serological IgG repertoire elicited by egg-based, cell-based, or recombinant haemagglutinin-based seasonal influenza vaccines: a comparative, prospective, observational cohort study.
Park J, Bartzoka F, von Beck T, Li ZN, Mishina M, Hebert LS, Kain J, Liu F, Sharma S, Cao W, Eddins DJ, Kumar A, Kim JE, Lee JS, Wang Y, Schwartz EA, Brilot AF, Satterwhite E, Towers DM, McKnight E, Pohl J, Thompson MG, Gaglani M, Dawood FS, Naleway AL, Stevens J, Kennedy RB, Jacob J, Lavinder JJ, Levine MZ, Gangappa S, Ippolito GC, Sambhara S, Georgiou G. Park J, et al. Among authors: georgiou g. Lancet Microbe. 2024 Dec 9:100935. doi: 10.1016/j.lanmic.2024.06.002. Online ahead of print. Lancet Microbe. 2024. PMID: 39667375 Free article.
769 results