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62 results

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Page 1
Microbiological profile, preclinical pharmacokinetics and efficacy of CRS0393, a novel antimycobacterial agent targeting MmpL3.
Ochsner UA, De Groote MA, Jarvis TC, Liu H, Youmans T, Hoang T, Ribble W, Day J, Li W, Pearce C, Walz A, Panthi CM, Rimal B, Stevens CM, Zgurskaya HI, Jackson M, Ordway D, Gonzalez-Juarrero M, Sun X, Lamichhane G, Mason C. Ochsner UA, et al. Tuberculosis (Edinb). 2023 Jan;138:102288. doi: 10.1016/j.tube.2022.102288. Epub 2022 Nov 29. Tuberculosis (Edinb). 2023. PMID: 36470124 Free PMC article.
Multiple-Ascending-Dose Phase 1 Clinical Study of the Safety, Tolerability, and Pharmacokinetics of CRS3123, a Narrow-Spectrum Agent with Minimal Disruption of Normal Gut Microbiota.
Lomeli BK, Galbraith H, Schettler J, Saviolakis GA, El-Amin W, Osborn B, Ravel J, Hazleton K, Lozupone CA, Evans RJ, Bell SJ, Ochsner UA, Jarvis TC, Baqar S, Janjic N. Lomeli BK, et al. Among authors: ochsner ua. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01395-19. doi: 10.1128/AAC.01395-19. Print 2019 Dec 20. Antimicrob Agents Chemother. 2019. PMID: 31685472 Free PMC article. Clinical Trial.
Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease.
Scriba TJ, Penn-Nicholson A, Shankar S, Hraha T, Thompson EG, Sterling D, Nemes E, Darboe F, Suliman S, Amon LM, Mahomed H, Erasmus M, Whatney W, Johnson JL, Boom WH, Hatherill M, Valvo J, De Groote MA, Ochsner UA, Aderem A, Hanekom WA, Zak DE; other members of the ACS cohort study team. Scriba TJ, et al. Among authors: ochsner ua. PLoS Pathog. 2017 Nov 16;13(11):e1006687. doi: 10.1371/journal.ppat.1006687. eCollection 2017 Nov. PLoS Pathog. 2017. PMID: 29145483 Free PMC article. Clinical Trial.
Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications.
Russell TM, Green LS, Rice T, Kruh-Garcia NA, Dobos K, De Groote MA, Hraha T, Sterling DG, Janjic N, Ochsner UA. Russell TM, et al. Among authors: ochsner ua. J Clin Microbiol. 2017 Oct;55(10):3072-3088. doi: 10.1128/JCM.00469-17. Epub 2017 Aug 9. J Clin Microbiol. 2017. PMID: 28794178 Free PMC article.
Safety, Tolerability, Systemic Exposure, and Metabolism of CRS3123, a Methionyl-tRNA Synthetase Inhibitor Developed for Treatment of Clostridium difficile, in a Phase 1 Study.
Nayak SU, Griffiss JM, Blumer J, O'Riordan MA, Gray W, McKenzie R, Jurao RA, An AT, Le M, Bell SJ, Ochsner UA, Jarvis TC, Janjic N, Zenilman JM. Nayak SU, et al. Among authors: ochsner ua. Antimicrob Agents Chemother. 2017 Jul 25;61(8):e02760-16. doi: 10.1128/AAC.02760-16. Print 2017 Aug. Antimicrob Agents Chemother. 2017. PMID: 28584140 Free PMC article. Clinical Trial.
Correction for De Groote et al., "Highly Multiplexed Proteomic Analysis of Quantiferon Supernatants To Identify Biomarkers of Latent Tuberculosis Infection".
De Groote MA, Higgins M, Hraha T, Wall K, Wilson ML, Sterling DG, Janjic N, Reves R, Ochsner UA, Belknap R. De Groote MA, et al. Among authors: ochsner ua. J Clin Microbiol. 2017 May;55(5):1598. doi: 10.1128/JCM.00333-17. J Clin Microbiol. 2017. PMID: 28442616 Free PMC article. No abstract available.
62 results