Garcia HG - Search Results

1

Predictive modeling reveals that higher-order cooperativity drives transcriptional repression in a synthetic developmental enhancer.

Kim YJ, Rhee K, Liu J, Jeammet S, Turner MA, Small SJ, Garcia HG. Kim YJ, et al. Among authors: garcia hg. Elife. 2022 Dec 12;11:e73395. doi: 10.7554/eLife.73395. Elife. 2022. PMID: 36503705 Free PMC article.

2

Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo.

Bothma JP, Garcia HG, Ng S, Perry MW, Gregor T, Levine M. Bothma JP, et al. Among authors: garcia hg. Elife. 2015 Aug 12;4:e07956. doi: 10.7554/eLife.07956. Elife. 2015. PMID: 26267217 Free PMC article.

3

Lighting up the central dogma for predictive developmental biology.

Garcia HG, Berrocal A, Kim YJ, Martini G, Zhao J. Garcia HG, et al. Curr Top Dev Biol. 2020;137:1-35. doi: 10.1016/bs.ctdb.2019.10.010. Epub 2019 Nov 22. Curr Top Dev Biol. 2020. PMID: 32143740 Review.

4

Quantitative dissection of transcription in development yields evidence for transcription-factor-driven chromatin accessibility.

Eck E, Liu J, Kazemzadeh-Atoufi M, Ghoreishi S, Blythe SA, Garcia HG. Eck E, et al. Among authors: garcia hg. Elife. 2020 Oct 19;9:e56429. doi: 10.7554/eLife.56429. Elife. 2020. PMID: 33074101 Free PMC article.

5

A matter of time: Using dynamics and theory to uncover mechanisms of transcriptional bursting.

Lammers NC, Kim YJ, Zhao J, Garcia HG. Lammers NC, et al. Among authors: garcia hg. Curr Opin Cell Biol. 2020 Dec;67:147-157. doi: 10.1016/j.ceb.2020.08.001. Epub 2020 Nov 24. Curr Opin Cell Biol. 2020. PMID: 33242838 Free PMC article. Review.

6

Kinetic sculpting of the seven stripes of the Drosophila even-skipped gene.

Berrocal A, Lammers NC, Garcia HG, Eisen MB. Berrocal A, et al. Among authors: garcia hg. Elife. 2020 Dec 10;9:e61635. doi: 10.7554/eLife.61635. Elife. 2020. PMID: 33300492 Free PMC article.

7

Real-time single-cell characterization of the eukaryotic transcription cycle reveals correlations between RNA initiation, elongation, and cleavage.

Liu J, Hansen D, Eck E, Kim YJ, Turner M, Alamos S, Garcia HG. Liu J, et al. Among authors: garcia hg. PLoS Comput Biol. 2021 May 18;17(5):e1008999. doi: 10.1371/journal.pcbi.1008999. eCollection 2021 May. PLoS Comput Biol. 2021. PMID: 34003867 Free PMC article.

8

Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in Drosophila.

Child MB 6th, Bateman JR, Jahangiri A, Reimer A, Lammers NC, Sabouni N, Villamarin D, McKenzie-Smith GC, Johnson JE, Jost D, Garcia HG. Child MB 6th, et al. Among authors: garcia hg. Elife. 2021 Jun 8;10:e64412. doi: 10.7554/eLife.64412. Elife. 2021. PMID: 34100718 Free PMC article.

9

Minimal synthetic enhancers reveal control of the probability of transcriptional engagement and its timing by a morphogen gradient.

Alamos S, Reimer A, Westrum C, Turner MA, Talledo P, Zhao J, Luu E, Garcia HG. Alamos S, et al. Among authors: garcia hg. Cell Syst. 2023 Mar 15;14(3):220-236.e3. doi: 10.1016/j.cels.2022.12.008. Epub 2023 Jan 24. Cell Syst. 2023. PMID: 36696901 Free PMC article.

10

Targeted mutagenesis of specific genomic DNA sequences in animals for the in vivo generation of variant libraries.

Falo-Sanjuan J, Diaz-Tirado Y, Turner MA, Davis J, Medrano C, Haines J, McKenna J, Karshenas A, Eisen MB, Garcia HG. Falo-Sanjuan J, et al. Among authors: garcia hg. bioRxiv [Preprint]. 2024 Oct 24:2024.06.10.598328. doi: 10.1101/2024.06.10.598328. bioRxiv. 2024. PMID: 38915503 Free PMC article. Preprint.

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