Zhou J - Search Results

1

Design, synthesis, and pharmacological evaluations of pyrrolo[1,2-a]quinoxaline-based derivatives as potent and selective sirt6 activators.

Xu J, Shi S, Liu G, Xie X, Li J, Bolinger AA, Chen H, Zhang W, Shi PY, Liu H, Zhou J. Xu J, et al. Among authors: zhou j. Eur J Med Chem. 2023 Jan 15;246:114998. doi: 10.1016/j.ejmech.2022.114998. Epub 2022 Dec 6. Eur J Med Chem. 2023. PMID: 36508969 Free PMC article.

2

Identification and characterization of small molecules as potent and specific EPAC2 antagonists.

Chen H, Tsalkova T, Chepurny OG, Mei FC, Holz GG, Cheng X, Zhou J. Chen H, et al. Among authors: zhou j. J Med Chem. 2013 Feb 14;56(3):952-62. doi: 10.1021/jm3014162. Epub 2013 Jan 15. J Med Chem. 2013. PMID: 23286832 Free PMC article.

3

Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy.

Chen H, Yang Z, Ding C, Chu L, Zhang Y, Terry K, Liu H, Shen Q, Zhou J. Chen H, et al. Among authors: zhou j. Eur J Med Chem. 2013 Apr;62:498-507. doi: 10.1016/j.ejmech.2013.01.023. Epub 2013 Jan 26. Eur J Med Chem. 2013. PMID: 23416191 Free PMC article.

4

Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents.

Chen H, Yang Z, Ding C, Chu L, Zhang Y, Terry K, Liu H, Shen Q, Zhou J. Chen H, et al. Among authors: zhou j. ACS Med Chem Lett. 2013 Feb 14;4(2):180-185. doi: 10.1021/ml3003082. Epub 2013 Jan 15. ACS Med Chem Lett. 2013. PMID: 23459613 Free PMC article.

5

Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility.

Ding C, Zhang Y, Chen H, Yang Z, Wild C, Chu L, Liu H, Shen Q, Zhou J. Ding C, et al. Among authors: zhou j. J Med Chem. 2013 Jun 27;56(12):5048-58. doi: 10.1021/jm400367n. Epub 2013 Jun 19. J Med Chem. 2013. PMID: 23746196 Free PMC article.

6

Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis.

Ding C, Zhang Y, Chen H, Yang Z, Wild C, Ye N, Ester CD, Xiong A, White MA, Shen Q, Zhou J. Ding C, et al. Among authors: zhou j. J Med Chem. 2013 Nov 14;56(21):8814-25. doi: 10.1021/jm401248x. Epub 2013 Oct 31. J Med Chem. 2013. PMID: 24128046 Free PMC article.

7

Small molecule inhibitors targeting activator protein 1 (AP-1).

Ye N, Ding Y, Wild C, Shen Q, Zhou J. Ye N, et al. Among authors: zhou j. J Med Chem. 2014 Aug 28;57(16):6930-48. doi: 10.1021/jm5004733. Epub 2014 May 27. J Med Chem. 2014. PMID: 24831826 Free PMC article.

8

Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo.

Chen H, Mrazek AA, Wang X, Ding C, Ding Y, Porro LJ, Liu H, Chao C, Hellmich MR, Zhou J. Chen H, et al. Among authors: zhou j. Bioorg Med Chem. 2014 Jul 1;22(13):3393-404. doi: 10.1016/j.bmc.2014.04.043. Epub 2014 May 2. Bioorg Med Chem. 2014. PMID: 24837156 Free PMC article.

9

Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3).

Chen H, Yang Z, Ding C, Xiong A, Wild C, Wang L, Ye N, Cai G, Flores RM, Ding Y, Shen Q, Zhou J. Chen H, et al. Among authors: zhou j. Eur J Med Chem. 2014 Jul 23;82:195-203. doi: 10.1016/j.ejmech.2014.05.049. Epub 2014 May 22. Eur J Med Chem. 2014. PMID: 24904966 Free PMC article.

10

Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents.

Chen H, Gao Y, Wang A, Zhou X, Zheng Y, Zhou J. Chen H, et al. Among authors: zhou x, zhou j. Eur J Med Chem. 2015 Mar 6;92:648-55. doi: 10.1016/j.ejmech.2015.01.031. Epub 2015 Jan 16. Eur J Med Chem. 2015. PMID: 25617694 Free PMC article. Review.

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