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Systematic Investigation of the Permeability of Androgen Receptor PROTACs.
Scott DE, Rooney TPC, Bayle ED, Mirza T, Willems HMG, Clarke JH, Andrews SP, Skidmore J. Scott DE, et al. Among authors: clarke jh. ACS Med Chem Lett. 2020 Jun 8;11(8):1539-1547. doi: 10.1021/acsmedchemlett.0c00194. eCollection 2020 Aug 13. ACS Med Chem Lett. 2020. PMID: 32832021 Free PMC article.
Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.
Boffey HK, Rooney TPC, Willems HMG, Edwards S, Green C, Howard T, Ogg D, Romero T, Scott DE, Winpenny D, Duce J, Skidmore J, Clarke JH, Andrews SP. Boffey HK, et al. Among authors: clarke jh. J Med Chem. 2022 Feb 24;65(4):3359-3370. doi: 10.1021/acs.jmedchem.1c01819. Epub 2022 Feb 11. J Med Chem. 2022. PMID: 35148092 Free PMC article.
Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor.
Willems HMG, Edwards S, Boffey HK, Chawner SJ, Green C, Romero T, Winpenny D, Skidmore J, Clarke JH, Andrews SP. Willems HMG, et al. Among authors: clarke jh. RSC Med Chem. 2023 Apr 17;14(5):934-946. doi: 10.1039/d3md00039g. eCollection 2023 May 25. RSC Med Chem. 2023. PMID: 37252102 Free PMC article.
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.
Taylor LW, Simzer EM, Pimblett C, Lacey-Solymar OTT, McGeachan RI, Meftah S, Rose JL, Spires-Jones MP, Holt K, Catterson JH, Koch H, Liaquat I, Clarke JH, Skidmore J, Smith C, Booker SA, Brennan PM, Spires-Jones TL, Durrant CS. Taylor LW, et al. Among authors: clarke jh. Acta Neuropathol. 2024 Jan 4;147(1):7. doi: 10.1007/s00401-023-02667-w. Acta Neuropathol. 2024. PMID: 38175261 Free PMC article.
117 results