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Extensive targeting of chemical space at the prime side of ketoamide inhibitors of rhomboid proteases by branched substituents empowers their selectivity and potency.
Bach K, Dohnálek J, Škerlová J, Kuzmík J, Poláchová E, Stanchev S, Majer P, Fanfrlík J, Pecina A, Řezáč J, Lepšík M, Borshchevskiy V, Polovinkin V, Strisovsky K. Bach K, et al. Eur J Med Chem. 2024 Sep 5;275:116606. doi: 10.1016/j.ejmech.2024.116606. Epub 2024 Jun 17. Eur J Med Chem. 2024. PMID: 38901105 Free article.
The zymogenic form of SARS-CoV-2 main protease: A discrete target for drug discovery.
Novotný P, Humpolíčková J, Nováková V, Stanchev S, Stříšovský K, Zgarbová M, Weber J, Kryštůfek R, Starková J, Hradilek M, Moravcová A, Günterová J, Bach K, Majer P, Konvalinka J, Majerová T. Novotný P, et al. Among authors: bach k. J Biol Chem. 2024 Dec 13:108079. doi: 10.1016/j.jbc.2024.108079. Online ahead of print. J Biol Chem. 2024. PMID: 39675720 Free article.
4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL.
Ji S, Bach K, Miriyala VM, Dohnálek J, Riopedre-Fernandez M, Lepšík M, van de Plassche M, Vanhoutte R, Barniol-Xicota M, Moreira R, Strisovsky K, Verhelst SHL. Ji S, et al. Among authors: bach k. ACS Med Chem Lett. 2024 Nov 14;15(12):2101-2106. doi: 10.1021/acsmedchemlett.4c00384. eCollection 2024 Dec 12. ACS Med Chem Lett. 2024. PMID: 39691509
Patellofemoral Cartilage Injury and Treatment.
Bach K, Sherman SL, Stone AV, Yanke AB, Lansdown DA. Bach K, et al. Instr Course Lect. 2025;74:79-92. Instr Course Lect. 2025. PMID: 39745553 Review.
Intratracheal Budesonide Mixed With Surfactant for Extremely Preterm Infants: The PLUSS Randomized Clinical Trial.
Manley BJ, Kamlin COF, Donath SM, Francis KL, Cheong JLY, Dargaville PA, Dawson JA, Jacobs SE, Birch P, Resnick SM, Schmölzer GM, Law B, Bhatia R, Bach KP, de Waal K, Travadi JN, Koorts PJ, Berry MJ, Lui K, Rajadurai VS, Chandran S, Kluckow M, Cloete E, Broom MM, Stark MJ, Gordon A, Kodur V, Doyle LW, Davis PG, McKinlay CJD; PLUSS Trial Investigators. Manley BJ, et al. Among authors: bach kp. JAMA. 2024 Dec 10;332(22):1889-1899. doi: 10.1001/jama.2024.17380. JAMA. 2024. PMID: 39527075 Clinical Trial.
276 results