Rutledge PJ - Search Results

1

Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid.

Ball SR, Adamson JSP, Sullivan MA, Zimmermann MR, Lo V, Sanz-Hernandez M, Jiang X, Kwan AH, McKenzie ADJ, Werry EL, Knowles TPJ, Kassiou M, Meisl G, Todd MH, Rutledge PJ, Sunde M. Ball SR, et al. Among authors: rutledge pj. ACS Chem Neurosci. 2023 Jan 4;14(1):87-98. doi: 10.1021/acschemneuro.2c00498. Epub 2022 Dec 21. ACS Chem Neurosci. 2023. PMID: 36542544 Free PMC article.

2

tert-Butyl-dimethyl-silanol hemihydrate.

Barry SM, Mueller-Bunz H, Rutledge PJ. Barry SM, et al. Among authors: rutledge pj. Acta Crystallogr Sect E Struct Rep Online. 2008 May 30;64(Pt 6):o1174. doi: 10.1107/S1600536808015444. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21202681 Free PMC article.

3

Bio-inspired nitrile hydration by peptidic ligands based on L-cysteine, L-methionine or L-penicillamine and pyridine-2,6-dicarboxylic acid.

Byrne C, Houlihan KM, Devi P, Jensen P, Rutledge PJ. Byrne C, et al. Among authors: rutledge pj. Molecules. 2014 Dec 12;19(12):20751-67. doi: 10.3390/molecules191220751. Molecules. 2014. PMID: 25514220 Free PMC article.

4

The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site.

Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ. Clifton IJ, et al. Among authors: rutledge pj. FEBS Lett. 2013 Aug 19;587(16):2705-9. doi: 10.1016/j.febslet.2013.07.016. Epub 2013 Jul 13. FEBS Lett. 2013. PMID: 23860486 Free article.

5

A cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthase.

Stewart AC, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ. Stewart AC, et al. Among authors: rutledge pj. Chembiochem. 2007 Nov 5;8(16):2003-7. doi: 10.1002/cbic.200700176. Chembiochem. 2007. PMID: 17907118

6

Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight.

Howard-Jones AR, Elkins JM, Clifton IJ, Roach PL, Adlington RM, Baldwin JE, Rutledge PJ. Howard-Jones AR, et al. Among authors: rutledge pj. Biochemistry. 2007 Apr 24;46(16):4755-62. doi: 10.1021/bi062314q. Epub 2007 Mar 31. Biochemistry. 2007. PMID: 17397141

7

Unexpected oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N synthase.

Daruzzaman A, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ. Daruzzaman A, et al. Among authors: rutledge pj. Chembiochem. 2006 Feb;7(2):351-8. doi: 10.1002/cbic.200500282. Chembiochem. 2006. PMID: 16444759

8

Alternative oxidation by isopenicillin N synthase observed by X-ray diffraction.

Ogle JM, Clifton IJ, Rutledge PJ, Elkins JM, Burzlaff NI, Adlington RM, Roach PL, Baldwin JE. Ogle JM, et al. Among authors: rutledge pj. Chem Biol. 2001 Dec;8(12):1231-7. doi: 10.1016/s1074-5521(01)00090-4. Chem Biol. 2001. PMID: 11755401

9

The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue.

Daruzzaman A, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ. Daruzzaman A, et al. Among authors: rutledge pj. Arch Biochem Biophys. 2013 Feb 1;530(1):48-53. doi: 10.1016/j.abb.2012.12.012. Epub 2012 Dec 19. Arch Biochem Biophys. 2013. PMID: 23262315

10

Resorculins: hybrid polyketide macrolides from Streptomyces sp. MST-91080.

Lacey HJ, Chen R, Vuong D, Lacey E, Rutledge PJ, Chooi YH, Piggott AM, Booth TJ. Lacey HJ, et al. Among authors: rutledge pj. Org Biomol Chem. 2023 Mar 22;21(12):2531-2538. doi: 10.1039/d2ob02332f. Org Biomol Chem. 2023. PMID: 36876905

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