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Page 1
Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption.
Pereira Ribeiro S, Strongin Z, Soudeyns H, Ten-Caten F, Ghneim K, Pacheco Sanchez G, Xavier de Medeiros G, Del Rio Estrada PM, Pelletier AN, Hoang T, Nguyen K, Harper J, Jean S, Wallace C, Balderas R, Lifson JD, Raghunathan G, Rimmer E, Pastuskova C, Wu G, Micci L, Ribeiro RM, Chan CN, Estes JD, Silvestri G, Gorman DM, Howell BJ, Hazuda DJ, Paiardini M, Sekaly RP. Pereira Ribeiro S, et al. Among authors: howell bj. Nat Immunol. 2024 Oct;25(10):1900-1912. doi: 10.1038/s41590-024-01952-4. Epub 2024 Sep 12. Nat Immunol. 2024. PMID: 39266691 Free PMC article.
Recommendations for measuring HIV reservoir size in cure-directed clinical trials.
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR, Spivak AM, Planelles V, Hahn BH, Smith DM, Ho YC, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I, Riley JL, Tebas P, Montaner LJ; BEAT-HIV Delaney Collaboratory to Cure HIV-1 infection. Abdel-Mohsen M, et al. Among authors: howell bj. Nat Med. 2020 Sep;26(9):1339-1350. doi: 10.1038/s41591-020-1022-1. Epub 2020 Sep 7. Nat Med. 2020. PMID: 32895573 Free PMC article. Review.
Initial productive and latent HIV infections originate in vivo by infection of resting T cells.
Wietgrefe SW, Anderson J, Duan L, Southern PJ, Zuck P, Wu G, Howell BJ, Reilly C, Kroon E, Chottanapund S, Buranapraditkun S, Sacdalan C, Tulmethakaan N, Colby DJ, Chomchey N, Prueksakaew P, Pinyakorn S, Trichavaroj R, Mitchell JL, Trautmann L, Hsu D, Vasan S, Manasnayakorn S, de Souza M, Tovanabutra S, Schuetz A, Robb ML, Phanuphak N, Ananworanich J, Schacker TW, Haase AT; RV254/SEARCH 010 Study Team. Wietgrefe SW, et al. Among authors: howell bj. J Clin Invest. 2023 Nov 15;133(22):e171501. doi: 10.1172/JCI171501. J Clin Invest. 2023. PMID: 37733443 Free PMC article.
A high-throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell-based assays.
Kasper SH, Otten S, Squadroni B, Orr-Terry C, Kuang Y, Mussallem L, Ge L, Yan L, Kannan S, Verma CS, Brown CJ, Johannes CW, Lane DP, Chandramohan A, Partridge AW, Roberts LR, Josien H, Therien AG, Hett EC, Howell BJ, Peier A, Ai X, Cassaday J. Kasper SH, et al. Among authors: howell bj. Bioeng Transl Med. 2023 May 13;8(5):e10542. doi: 10.1002/btm2.10542. eCollection 2023 Sep. Bioeng Transl Med. 2023. PMID: 37693049 Free PMC article.
Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1.
Balibar CJ, Klein DJ, Zamlynny B, Diamond TL, Fang Z, Cheney CA, Kristoff J, Lu M, Bukhtiyarova M, Ou Y, Xu M, Ba L, Carroll SS, El Marrouni A, Fay JF, Forster A, Goh SL, Gu M, Krosky D, Rosenbloom DIS, Sheth P, Wang D, Wu G, Zebisch M, Zhao T, Zuck P, Grobler J, Hazuda DJ, Howell BJ, Converso A. Balibar CJ, et al. Among authors: howell bj. Sci Transl Med. 2023 Feb 22;15(684):eabn2038. doi: 10.1126/scitranslmed.abn2038. Epub 2023 Feb 22. Sci Transl Med. 2023. PMID: 36812345
A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
Moore KP, Schwaid AG, Tudor M, Park S, Beshore DC, Converso A, Shipe WD, Anand R, Lan P, Moningka R, Rothman DM, Sun W, Chi A, Cornella-Taracido I, Adam GC, Bahnck-Teets C, Carroll SS, Fay JF, Goh SL, Lusen J, Quan S, Rodriguez S, Xu M, Andrews CL, Song C, Filzen T, Li J, Hollenstein K, Klein DJ, Lammens A, Lim UM, Fang Z, McHale C, Li Y, Lu M, Diamond TL, Howell BJ, Zuck P, Balibar CJ. Moore KP, et al. Among authors: howell bj. ACS Chem Biol. 2022 Sep 16;17(9):2595-2604. doi: 10.1021/acschembio.2c00515. Epub 2022 Aug 31. ACS Chem Biol. 2022. PMID: 36044633
Participant experiences using novel home-based blood collection device for viral load testing in HIV cure trials with analytical treatment interruptions.
Dubé K, Agarwal H, Carter WB, Dee L, Taylor J, Roebuck C, Peterson B, Patel H, Ndukwe S, Lynn KM, Lalley-Chareczko L, Hiserodt E, Kim S, Rosenbloom D, Evans BR, Anderson M, Hazuda DJ, Bateman K, Howell BJ, Azzoni L, Mounzer K, Tebas P, Montaner LJ. Dubé K, et al. Among authors: howell bj. HIV Res Clin Pract. 2022 Aug 2;23(1):76-90. HIV Res Clin Pract. 2022. PMID: 35968737 Free PMC article.
Detecting Sources of Immune Activation and Viral Rebound in HIV Infection.
Wietgrefe SW, Duan L, Anderson J, Marqués G, Sanders M, Cummins NW, Badley AD, Dobrowolski C, Karn J, Pagliuzza A, Chomont N, Sannier G, Dubé M, Kaufmann DE, Zuck P, Wu G, Howell BJ, Reilly C, Herschhorn A, Schacker TW, Haase AT. Wietgrefe SW, et al. Among authors: howell bj. J Virol. 2022 Aug 10;96(15):e0088522. doi: 10.1128/jvi.00885-22. Epub 2022 Jul 20. J Virol. 2022. PMID: 35856674 Free PMC article.
70 results