Flatt PR - Search Results

1

Evidence for Involvement of GIP and GLP-1 Receptors and the Gut-Gonadal Axis in Regulating Female Reproductive Function in Mice.

Khan D, Ojo OO, Woodward OR, Lewis JE, Sridhar A, Gribble FM, Reimann F, Flatt PR, Moffett RC. Khan D, et al. Among authors: flatt pr. Biomolecules. 2022 Nov 23;12(12):1736. doi: 10.3390/biom12121736. Biomolecules. 2022. PMID: 36551163 Free PMC article.

2

Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo.

Gault VA, Parker JC, Harriott P, Flatt PR, O'Harte FP. Gault VA, et al. Among authors: flatt pr. J Endocrinol. 2002 Nov;175(2):525-33. doi: 10.1677/joe.0.1750525. J Endocrinol. 2002. PMID: 12429050

3

Effects of the novel (Pro3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin.

Gault VA, O'Harte FP, Harriott P, Mooney MH, Green BD, Flatt PR. Gault VA, et al. Among authors: flatt pr. Diabetologia. 2003 Feb;46(2):222-30. doi: 10.1007/s00125-002-1028-x. Epub 2003 Feb 12. Diabetologia. 2003. PMID: 12627321

4

Glucose-dependent insulinotropic polypeptide (GIP): anti-diabetic and anti-obesity potential?

Gault VA, O'Harte FP, Flatt PR. Gault VA, et al. Among authors: flatt pr. Neuropeptides. 2003 Oct;37(5):253-63. doi: 10.1016/j.npep.2003.09.002. Neuropeptides. 2003. PMID: 14607102 Review.

5

Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid.

Green BD, Gault VA, Flatt PR, Harriott P, Greer B, O'Harte FP. Green BD, et al. Among authors: flatt pr. Arch Biochem Biophys. 2004 Aug 15;428(2):136-43. doi: 10.1016/j.abb.2004.05.005. Arch Biochem Biophys. 2004. PMID: 15246869

6

Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice.

Irwin N, Gault VA, Green BD, Greer B, McCluskey JT, Harriott P, O'Harte FP, Flatt PR. Irwin N, et al. Among authors: flatt pr. Biol Chem. 2004 Sep;385(9):845-52. doi: 10.1515/BC.2004.110. Biol Chem. 2004. PMID: 15493880

7

Structurally modified analogues of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) as future antidiabetic agents.

Green BD, Gault VA, O'harte FP, Flatt PR. Green BD, et al. Among authors: flatt pr. Curr Pharm Des. 2004;10(29):3651-62. doi: 10.2174/1381612043382774. Curr Pharm Des. 2004. PMID: 15579061 Review.

8

Effects on glucose homeostasis and insulin secretion of long term activation of the glucose-dependent insulinotropic polypeptide (GIP) receptor by N-AcGIP(LysPAL37) in normal mice.

Irwin N, Green BD, Gault VA, Cassidy RS, O'Harte FP, Harriott P, Flatt PR. Irwin N, et al. Among authors: flatt pr. Peptides. 2006 Apr;27(4):893-900. doi: 10.1016/j.peptides.2005.08.003. Epub 2005 Sep 21. Peptides. 2006. PMID: 16181707

9

Stable agonist of glucose-dependent insulinotropic polypeptide (GIP) restores pancreatic beta cell glucose responsiveness but not glucose intolerance in aging mice.

Irwin N, Green BD, Gault VA, Harriot P, O'Harte FP, Flatt PR. Irwin N, et al. Among authors: flatt pr. Exp Gerontol. 2006 Feb;41(2):151-6. doi: 10.1016/j.exger.2005.11.006. Epub 2005 Dec 27. Exp Gerontol. 2006. PMID: 16378704

10

Biological activity and antidiabetic potential of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide, GIP(1-16) and (Pro3)GIP(1-16).

Irwin N, Green BD, Parker JC, Gault VA, O'Harte FP, Flatt PR. Irwin N, et al. Among authors: flatt pr. Regul Pept. 2006 Jul 15;135(1-2):45-53. doi: 10.1016/j.regpep.2006.03.006. Epub 2006 May 3. Regul Pept. 2006. PMID: 16675042

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