Jost M - Search Results

1

Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors.

Replogle JM, Bonnar JL, Pogson AN, Liem CR, Maier NK, Ding Y, Russell BJ, Wang X, Leng K, Guna A, Norman TM, Pak RA, Ramos DM, Ward ME, Gilbert LA, Kampmann M, Weissman JS, Jost M. Replogle JM, et al. Among authors: jost m. Elife. 2022 Dec 28;11:e81856. doi: 10.7554/eLife.81856. Elife. 2022. PMID: 36576240 Free PMC article.

2

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response.

Adamson B, Norman TM, Jost M, Cho MY, Nuñez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman JS. Adamson B, et al. Among authors: jost m. Cell. 2016 Dec 15;167(7):1867-1882.e21. doi: 10.1016/j.cell.2016.11.048. Cell. 2016. PMID: 27984733 Free PMC article.

3

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent.

Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. Jost M, et al. Mol Cell. 2017 Oct 5;68(1):210-223.e6. doi: 10.1016/j.molcel.2017.09.012. Mol Cell. 2017. PMID: 28985505 Free PMC article.

4

CRISPR Approaches to Small Molecule Target Identification.

Jost M, Weissman JS. Jost M, et al. ACS Chem Biol. 2018 Feb 16;13(2):366-375. doi: 10.1021/acschembio.7b00965. Epub 2018 Jan 25. ACS Chem Biol. 2018. PMID: 29261286 Free PMC article. Review.

5

Molecular recording of mammalian embryogenesis.

Chan MM, Smith ZD, Grosswendt S, Kretzmer H, Norman TM, Adamson B, Jost M, Quinn JJ, Yang D, Jones MG, Khodaverdian A, Yosef N, Meissner A, Weissman JS. Chan MM, et al. Among authors: jost m. Nature. 2019 Jun;570(7759):77-82. doi: 10.1038/s41586-019-1184-5. Epub 2019 May 13. Nature. 2019. PMID: 31086336 Free PMC article.

6

Exploring genetic interaction manifolds constructed from rich single-cell phenotypes.

Norman TM, Horlbeck MA, Replogle JM, Ge AY, Xu A, Jost M, Gilbert LA, Weissman JS. Norman TM, et al. Among authors: jost m. Science. 2019 Aug 23;365(6455):786-793. doi: 10.1126/science.aax4438. Epub 2019 Aug 8. Science. 2019. PMID: 31395745 Free PMC article.

7

Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs.

Jost M, Santos DA, Saunders RA, Horlbeck MA, Hawkins JS, Scaria SM, Norman TM, Hussmann JA, Liem CR, Gross CA, Weissman JS. Jost M, et al. Nat Biotechnol. 2020 Mar;38(3):355-364. doi: 10.1038/s41587-019-0387-5. Epub 2020 Jan 13. Nat Biotechnol. 2020. PMID: 31932729 Free PMC article.

8

Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent.

Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. Jost M, et al. Mol Cell. 2020 Jul 2;79(1):191-198.e3. doi: 10.1016/j.molcel.2020.06.008. Mol Cell. 2020. PMID: 32619469 Free PMC article.

9

GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.

Hickey KL, Dickson K, Cogan JZ, Replogle JM, Schoof M, D'Orazio KN, Sinha NK, Hussmann JA, Jost M, Frost A, Green R, Weissman JS, Kostova KK. Hickey KL, et al. Among authors: jost m. Mol Cell. 2020 Sep 17;79(6):950-962.e6. doi: 10.1016/j.molcel.2020.07.007. Epub 2020 Jul 28. Mol Cell. 2020. PMID: 32726578 Free PMC article.

10

Mismatch-CRISPRi Reveals the Co-varying Expression-Fitness Relationships of Essential Genes in Escherichia coli and Bacillus subtilis.

Hawkins JS, Silvis MR, Koo BM, Peters JM, Osadnik H, Jost M, Hearne CC, Weissman JS, Todor H, Gross CA. Hawkins JS, et al. Among authors: jost m. Cell Syst. 2020 Nov 18;11(5):523-535.e9. doi: 10.1016/j.cels.2020.09.009. Epub 2020 Oct 19. Cell Syst. 2020. PMID: 33080209 Free PMC article.

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