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Page 1
Roadmap for precision preclinical x-ray radiation studies.
Verhaegen F, Butterworth KT, Chalmers AJ, Coppes RP, de Ruysscher D, Dobiasch S, Fenwick JD, Granton PV, Heijmans SHJ, Hill MA, Koumenis C, Lauber K, Marples B, Parodi K, Persoon LCGG, Staut N, Subiel A, Vaes RDW, van Hoof S, Verginadis IL, Wilkens JJ, Williams KJ, Wilson GD, Dubois LJ. Verhaegen F, et al. Among authors: koumenis c. Phys Med Biol. 2023 Mar 31;68(6). doi: 10.1088/1361-6560/acaf45. Phys Med Biol. 2023. PMID: 36584393 Free article. Review.
FLASH Proton Radiation Therapy Mitigates Inflammatory and Fibrotic Pathways and Preserves Cardiac Function in a Preclinical Mouse Model of Radiation-Induced Heart Disease.
Kim K, Kim MM, Skoufos G, Diffenderfer ES, Motlagh SAO, Kokkorakis M, Koliaki I, Morcos G, Shoniyozov K, Griffin J, Hatzigeorgiou AG, Metz JM, Lin A, Feigenberg SJ, Cengel KA, Ky B, Koumenis C, Verginadis II. Kim K, et al. Among authors: koumenis c. Int J Radiat Oncol Biol Phys. 2024 Jul 15;119(4):1234-1247. doi: 10.1016/j.ijrobp.2024.01.224. Epub 2024 Feb 15. Int J Radiat Oncol Biol Phys. 2024. PMID: 38364948 Free PMC article.
Proton radiation boosts the efficacy of mesothelin-targeting chimeric antigen receptor T cell therapy in pancreatic cancer.
Amit U, Uslu U, Verginadis II, Kim MM, Motlagh SAO, Diffenderfer ES, Assenmacher CA, Bicher S, Atoche SJ, Ben-Josef E, Young RM, June CH, Koumenis C. Amit U, et al. Among authors: koumenis c. Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2403002121. doi: 10.1073/pnas.2403002121. Epub 2024 Jul 24. Proc Natl Acad Sci U S A. 2024. PMID: 39047033 Free PMC article.
Early Inflammation and Interferon Signaling Direct Enhanced Intestinal Crypt Regeneration after Proton FLASH Radiotherapy.
Lim TL, Morral C, Verginadis II, Kim K, Luo L, Foley CJ, Kim MM, Li N, Yoshor B, Njah K, Putt M, Oliaei Motlagh SA, Velalopoulou A, Chowdhury P, Bicher S, Goia D, Lengner CJ, Wrana JL, Koumenis C, Minn AJ. Lim TL, et al. Among authors: koumenis c. bioRxiv [Preprint]. 2024 Aug 19:2024.08.16.608284. doi: 10.1101/2024.08.16.608284. bioRxiv. 2024. PMID: 39229237 Free PMC article. Preprint.
Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies.
Lu Z, Verginadis I, Kumazoe M, Castillo GM, Yao Y, Guerra RE, Bicher S, You M, McClung G, Qiu R, Xiao Z, Miao Z, George SS, Beiting DP, Nojiri T, Tanaka Y, Fujimura Y, Onda H, Hatakeyama Y, Nishimoto-Ashfield A, Bykova K, Guo W, Fan Y, Buynov NM, Diehl JA, Stanger BZ, Tachibana H, Gade TP, Puré E, Koumenis C, Bolotin EM, Fuchs SY. Lu Z, et al. Among authors: koumenis c. Sci Transl Med. 2024 Aug 21;16(761):eadn0904. doi: 10.1126/scitranslmed.adn0904. Epub 2024 Aug 21. Sci Transl Med. 2024. PMID: 39167664
The ISR downstream target ATF4 represses long-term memory in a cell type-specific manner.
Mahmood N, Choi JH, Wu PY, Dooling SW, Watkins TA, Huang Z, Lipman J, Zhao H, Yang A, Silversmith J, Inglebert Y, Koumenis C, Sharma V, Lacaille JC, Sossin WS, Khoutorsky A, McKinney RA, Costa-Mattioli M, Sonenberg N. Mahmood N, et al. Among authors: koumenis c. Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2407472121. doi: 10.1073/pnas.2407472121. Epub 2024 Jul 24. Proc Natl Acad Sci U S A. 2024. PMID: 39047038
FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone.
Verginadis II, Velalopoulou A, Kim MM, Kim K, Paraskevaidis I, Bell B, Oliaei Motlagh SA, Karaj A, Banerjee E, Finesso G, Assenmacher CA, Radaelli E, Lu J, Lin Y, Putt ME, Diffenderfer ES, Guha C, Qin L, Metz JM, Maity A, Cengel KA, Koumenis C, Busch TM. Verginadis II, et al. Among authors: koumenis c. bioRxiv [Preprint]. 2024 Jul 11:2024.07.08.602528. doi: 10.1101/2024.07.08.602528. bioRxiv. 2024. PMID: 39026805 Free PMC article. Preprint.
168 results